LifeCare Chiropractic

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CRP

HEMOGLOBIN AND CHOLESTEROL PREDICT FUTURE CARDIOVASCULAR EVENTS – (11-30-03)

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Joint Effects of CRP, Glycated Hemoglobin in Predicting Future Cardiovascular Events of Patients With Advanced Atherosclerosis

Cholesterol? Didn’t somebody say cholesterol? Please?? I thought I heard someone, somewhere say cholesterol…

Circulation — Abstracts: Schillinger et al. 108 (19): 2323.

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CHOLESTEROL NOT A MAJOR RISK FACTOR OF CARDIOVASCULAR DISEASE – (11-30-03)

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Comparison of Apolipoprotein B and LDL-C with Other Cardiovascular Risk Factors in the Insulin Resistance Atherosclerosis Study (IRAS)

Whoa!!! Slow down here!! Mainstream medicince is still trying to swallow the idea that CRP and homocysteine are major risk factors for CVD!! We really shouldn’t throw too much research at clinicians all at once. Besides, if we start realizing that cholesterol isn’t the major risk factor for CVD, than what are we going to do with the billions and billions of dollars spent on statins??

Circulation — Abstracts: Williams et al. 108 (19): 2312.

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THE FACTORS THAT EXPLAIN MOST HEART ATTACKS – (10-04-04)

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Study indicates nine risk factors explain most heart attacks

So why is it still a major killer in the US? Maybe because we are still so focused on treatment and not prevention. Ironically, an abnormal ratio of apolipoprotein A to apolipoprotein B and smoking accounted for 2/3 of risk. So, while most clinicians are still checking only cholesterol, the real risk factors like apo A/apo B ratios, CRP and insulin resistance go unchecked. THESE ARE ALL MODIFYABLE RISK FACTORS. I don’t know what else to say except that we are a miserable failure when it comes to educating the public about prevention.

Study indicates nine risk factors explain most heart attacks — White 329 (7465): 527 — BMJ –

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MIXED DIETARY APPROACH LOWERS CHOLESTEROL AND CRP EFFECTS – (08-04-03)

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Effects of a Dietary Portfolio of Cholesterol-Lowering Foods vs Lovastatin on Serum Lipids and CRP

The pharmaceutical companies are scrambling to find a drug that lowers CRP levels. Well–look no further–Mother Nature has provided us with the tools already. In this study we find that a mixed dietary approach at lowering cholesterol and CRP was as effective as lovastatin.

I’m not being cynical here–I truly do wonder why a study like this published in JAMA does not get any press. Can the pharmaceutical influence be so powerful as to suppress this kind of info from the general public???

JAMA — Abstracts: Jenkins et al. 290 (4): 502

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DRUGS TO LOW CRP LEVELS AGAINST INFLAMMATION – (10-01-03)

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C-Reactive Protein

This is a nice review of CRP from a cardiology journal. CRP is a marker of inflammation that has only recently been given the attention is deserves. I have found in my office that exercise and avoiding refined carbs are powerful ways to lower CRP levels. Most of the research now with CRP is focusing on current and new drugs’ abilities to lower CRP. News flash–who needs drugs when lifestyle changes have already been proven to work??

Circulation — Ridker 108 (12): 81e

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EFFECT OF DIABETIC DRUG ON CRP LEVELS AFFECTING PATIENT’S LONG TERM HEALTH – (10-15-03)

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Metformin Reduces CRP in Women with Polycystic Ovary Syndrome

What I find interesting about this article is not that a diabetic drug could lower CRP levels (insulin will raise CRP levels–so if you lower insulin levels you will lower CRP as well) but that the standard care, aka the Pill, will increase CRP levels!! It seems like, in so many cases, the OB/GYN answer to most female problems is to use the pill to force a “normal” cycle on the patient. Yet this sets up a physiological state that is ultimately damaging to the patient’s long term health.

JCEM — Abstracts: Morin-Papunen et al. 88 (10): 4649

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LOW GRADE INFLAMMATION RISKS STIFFNESS IN HYPERCHOLESTROL – (06-10-04)

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Low-grade systemic inflammation impairs arterial stiffness in newly diagnosed hypercholesterolaemia

Sorry for the long title, but basically, CRP as a marker of inflammation and waist to hip ratio were a better marker for less elasticity in the aorta (not a good thing…) than “traditional” risk factors such as LDL and total cholesterol and blood pressure. It is still rare for me to see a CRP level come back from any labwork ordered from another physician. This is just another example of clinical practice running decades behind what is in the medical literature.

Low-grade systemic inflammation impairs arterial stiffness in newly diagnosed hypercholesterolaemia – Eur J Clin Invest, Vol .

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LEPTIN REGULATES OUR BODY WEIGHT – (08-28-06)

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Induction of leptin resistance through direct interaction of C-reactive protein with leptin

Wow. We’ve been trying to figure out how leptin–a hormone that’s supposed to keep our weight regulated by increasing metabolism w/ decreasing hunger when weight increases and doing the opposite when weight reduces–becomes less and less effective with obesity. Well, this may be a key.

When inflammation goes up, as determined by CRP levels, the CRP keeps leptin from working on a cell. Then abdominal obesity goes up and more inflammation is produced. What a nasty viscous circle.

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