Induction of leptin resistance through direct interaction of C-reactive protein with leptin
Wow. We’ve been trying to figure out how leptin–a hormone that’s supposed to keep our weight regulated by increasing metabolism w/ decreasing hunger when weight increases and doing the opposite when weight reduces–becomes less and less effective with obesity. Well, this may be a key.
When inflammation goes up, as determined by CRP levels, the CRP keeps leptin from working on a cell. Then abdominal obesity goes up and more inflammation is produced. What a nasty viscous circle.