Induction of leptin resistance through direct interaction of C-reactive protein with leptin

Wow. We’ve been trying to figure out how leptin–a hormone that’s supposed to keep our weight regulated by increasing metabolism w/ decreasing hunger when weight increases and doing the opposite when weight reduces–becomes less and less effective with obesity. Well, this may be a key.

When inflammation goes up, as determined by CRP levels, the CRP keeps leptin from working on a cell. Then abdominal obesity goes up and more inflammation is produced. What a nasty viscous circle.

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James Bogash

For more than a decade, Dr. Bogash has stayed current with the medical literature as it relates to physiology, disease prevention and disease management. He uses his knowledge to educate patients, the community and cyberspace on the best way to avoid and / or manage chronic diseases using lifestyle and targeted supplementation.