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Hormone

HRT Use Linked to Increased Risk of Asthma in Women – (11-23-00)

February 26, 2014 by James Bogash

HRT Use Linked to Increased Risk of Asthma in Women

Okay, okay. Explain to me again why HRT is consistantly one of the most heavily prescribed pharmaceuticals?? I just don’t understand. And why did these results not end up all over the news media?

(article) Hormone replacement therapy (HRT) is associated with an increased risk of adult-onset asthma but not chronic obstructive pulmonary disease (COPD), researches reported here at the annual meeting of the American College of Chest Physicians. Analysis of the data revealed that “current users of estrogen alone had an increased risk of asthma (RR 1.8) compared with never-users of HRT after adjustment for age and smoking,” and this risk increased with the dose and length of estrogen use. In addition, women who took estrogen and progestin and past users of HRT “had similarly elevated risks of asthma.” “This is a large increase in risk for developing asthma. However, the number of women who develop asthma in this age range is relatively small, particularly compared with those who develop heart disease or osteoporosis,” Dr. Barr told Reuters Health. Also, Dr. Barr pointed out, the analysis so far indicates that HRT is not associated with worsening of pre-existing asthma. Dr. Barr’s group also found that “current users of estrogen also were at increased risk of a new diagnosis of both asthma and COPD (RR 2.0) compared with never-users of HRT.” The risk of COPD alone was the same for HRT and non-HRT users, after adjusting for age and smoking, and there were no effects associated with dose or duration of HRT.

Filed Under: Hormone Tagged With: asthma, chronic obstructive pulmonary disease (COPD), Hormone replacement therapy, HRT

The Heart and Estrogen/Progestin Replacement Study Revisited – (11-12-00)

February 25, 2014 by James Bogash

The Heart and Estrogen/Progestin Replacement Study Revisited

Yet another nail in the coffin of HRT. This commentary is a review of recent evidence suggesting that HRT may actually worsen heart disease. With all the evidence coming out against artificial HRT (there needs to be a differentiation between horse estrogens and natural, human estrogens) and effective natural alternatives, I truly cannot understand why any woman would consider putting this into her body.

The Heart and Estrogen/Progestin Replacement Study Revisited: Hormone Replacement Therapy Produced Net Harm, Consistent With

Read entire article here

Filed Under: Heart Disease, Hormone Tagged With: Estrogen/Progestin, heart disease, HRT

Complex Hormonal Abnormalities Identified in Metabolic Syndrome – (11-09-00)

February 24, 2014 by James Bogash

Complex Hormonal Abnormalities Identified in Metabolic Syndrome

Syndrome X is a constellation of symptoms that many in medicine have failed to recognize, and yet it may be one of the single most important contributors to chronic disease today. It relates to an inability of insulin to do an effective job, and the body responds by producing more insulin. This elevation of insulin leads to many damaging effects on the body.’
(article) Complex interactions between increased insulin, cortisol and noradrenaline and decreased growth hormone and adrenaline appear to underlie the pathogenesis of the different components of the metabolic syndrome, according to Dr. Julian Critchley of The Chinese University of Hong Kong. Speaking at the Second Hong Kong Diabetes and Cardiovascular Risk Factors East Meets West Symposium, he reported on a study of 767 subjects recruited from the Prince of Wales Hospital and other Hong Kong clinics, including 60.9% with type 2 diabetes and/or hypertension and/or dyslipidemia, and 39.1% healthy individuals. “Our findings showed a clustering of pathophysiological abnormalities and risk factors to varying degrees. When compared to control subjects, patients either with only diabetes, only hypertension or only dyslipidemia were more generally and centrally obese, had higher plasma insulin, a higher insulin resistance index, higher cortisol and urinary noradrenaline but lower plasma growth hormone and urinary adrenaline excretion values,” Dr. Critchley reported.

Filed Under: Hormone Tagged With: chronic disease, Hormonal Abnormalities, metabolic syndrome

Mammography no better than physical breast examination – (10-30-00)

February 23, 2014 by James Bogash

Mammography no better than physical breast examination, study shows

There has been some debate recently in the medical literature as to whether or not a benefit clearly saves lives. Depending upon the research study you look at, mammography either extends survival or has no effect. And the jury is still out. The bottom line…avoid the issue with detection. Prevention is, has been, and always will be the best answer. Avoid saturated fats, alcohol, refined carbs and hormone replacement therapy. Get plenty of exercise and calcium-d-glucarate from fruits and veggies…

bmj.com 321 (7264): 788e

Read entire article here

Filed Under: Hormone Tagged With: breast examination, Hormone replacement therapy, mammography

Differential effects of oral vs transdermal ERT on CRP in postmenopausal – (04-23-03)

December 17, 2013 by James Bogash

Differential effects of oral vs transdermal ERT on CRP in postmenopausal

Hate to rely all my sad stories, but I had a woman in this week; 60 years old, multiple open heart surgeries, stent placement in both renal arteries and 3 strokes. You would think her cardiologists (a long stream of them) would at some point have discussed insulin management, homocysteine and CRP with her. Appearantly not. She is also currently on oral ERT which, as we see in this study raises CRP levels.

Cardiosource

Filed Under: Heart Disease, Stroke, Blood Pressure Tips, Hormone Tagged With: CRP, oral ERT, renal arteries, strokes, transdermal ERT

Effects of Estrogen plus Progestin on Health-Related Quality of Life – (03-18-03)

December 9, 2013 by James Bogash

Effects of Estrogen plus Progestin on Health-Related Quality of Life.

Sorry to be in the negative mode, but the subject of HRT is becoming so dead in the water that it is laughable. The drug companies are so desperately scrambling for a use for this multi billion dollar industry and keep striking out left and right. He we see no impact on sleep disturbance, physical functioning, and bodily pain. So..no benefits, but it does increase risk of gallstones, breast cancer, endometrial cancer and heart disease. Why the hell is this product still on the market? If this was a natural product it would’ve been yanked off the shelves faster than tryptophan in the eighties!!

NEJM — Effects of Estrogen plus Progestin on Health-Related Quality of Life.

Click here for more information.

Filed Under: Hormone Tagged With: estrogen, HRT, Progestin

Perchlorate in Water in AZ and Abnormal Neonatal Thyroid Function – (09-18-00)

November 19, 2013 by James Bogash

Perchlorate in Water in AZ and Abnormal Neonatal Thyroid Function

Yet another reason to be sure you drink properly filtered water. Ammonium perchlorite affects the thyroid’s ability to take up much needed iodide, thereby lowering the efficiency of the thyroid gland. This study suggests that even newborn infants are affected. Technology is surely killing us, albeit slowly.

J Occup Environ Med 2000;42:777-782 Ammonium perchlorate contamination of drinking water drawn from the Colorado River is associated with significantly elevated thyroid-stimulating hormone (TSH) levels in newborns. The Colorado River below Lake Mead supplies drinking water to approximately 20 million people. In their introduction, the authors of the report explain that the water is contaminated with ammonium perchlorate, which is used in the manufacture of rocket fuel, ammunition and fireworks, and which has been discarded in large quantities in Nevada since the 1950s. The perchlorate ion, they elaborate, can persist in water for long periods, and can act “as a competitive inhibitor of iodide transport in the thyroid.” Dr. Brechner and colleagues collected data on TSH levels from 1099 newborns in Yuma whose water is contaminated with ammonium perchlorate and from 443 newborns in Flagstaff whose drinking water has no detectable levels of ammonium perchlorate. The team found that the level of ammonium perchlorate contamination was 6 parts per billion in Yuma’s drinking water. After adjusting for age and for race/ethnicity and factors known or suspected to increase TSH levels in newborns, the investigators found that median TSH levels in the subjects exposed to ammonium perchlorate were significantly higher than those in the control group–19.9 vs 13.4 mU/L.

Filed Under: Hormone, Thyroid Tagged With: Neonatal Thyroid Function, Perchlorate, thyroid-stimulating hormone (TSH)

In Utero Estrogen Exposure Linked to Testicular Germ-Cell Cancer – (09-14-00)

November 12, 2013 by James Bogash

In Utero Estrogen Exposure Linked to Testicular Germ-Cell Cancer

More and more evidence is accumulating that suggests that a fetus’ exposure to chemicals in the womb can have long term effects. Recent studies suggest that maternal exposure to pesticides will increase the risk of a certain type of brain tumor in infants. This exposure to estrogen would include environmental estrogens (xenoestrogens) found as toxins in many foods.

Int J Cancer 2000;87:438-443 Prenatal exposure to maternal hormones, especially estrogen, appears to influence subsequent risk of developing testicular germ-cell cancer, according to researchers in Canada and the US. For instance, exposure to exogenous hormones (pregnancy tests or treatment for near miscarriage), preterm birth and first birth to a young mother were associated with an increased risk of testicular cancer. Maternal smoking during pregnancy (12 cigarettes per day or more), which is believed to have an “anti-estrogen” effect, decreased the risk of cancer. Bleeding or threatened miscarriage also reduced the risk of cancer, but the reason for this association is not yet clear, the investigators write. “Our results support the hypothesis that exposure to maternal hormones, particularly estrogen, is associated with testicular germ-cell cancer risk,” Dr. Weir and colleagues conclude. This link warrants further investigation in more “direct” studies, they believe.

Filed Under: Cancer, Hormone Tagged With: estrogen, Testicular Germ-Cell Cancer, xenoestrogens

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