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Hormone

DHEA Inhibits VSMC Proliferation Independent of ARs and ERs – (01-17-02)

March 10, 2013 by James Bogash

DHEA Inhibits VSMC Proliferation Independent of ARs and ERs

I know it’s a big, long, complicated title, but basically this study shows that DHEA has independent effects on reducing atherosclerosis. Although DHEA is produced by the adrenals and converted to testosterone and then estrogen, this is an example of a precurser hormone/molecule having physiologic effects. Pretty amazing. Now, I would not recommend running out and taking bottles of DHEA to lower risk of CVD. However, making sure that your adrenal glands are functioning optimally is very important to maintaining healthy, physiologicaly normal levels.

JCEM — Abstracts: Williams et al. 87 (1): 176

Read entire article here

Filed Under: Hormone, Testosterone Tagged With: atherosclerosis, DHEA, VSMC Proliferation

Resistin is a hormone that worsens insulin resistance – (04-08-04)

December 23, 2012 by James Bogash

Modulation of Resistin Expression by Retinoic Acid and Vitamin A Status

Speaking of Vit A’s bad rap…

Resistin is a hormone secreted by the fat cells that has been shown to worsen insulin resistance and overall make the obesity problem worse.

In this interesting article we see that retinoic acid (the acid form of Vit A) and Vitamin A given to mice actually lowers the genetic expression of resistin, thus improving insulin resistance and resulting in weight loss. What I would consider interesting here is that, given that Vitamin A is a fat soluble vitamin, it’s absorption would be impaired with gastric bypass surgery as well as patients will non-surgical digestion problems. Might poor digestion contribute to weight gain at least in part by reducing Vit A absoprtion? Just some food for thought…

Diabetes — Abstracts: Felipe et al. 53 (4): 882

Read entire article here

Filed Under: Hormone, Vitamins and Supplements 101 Tagged With: insulin resistance, resistin, Retinoic Acid, vitamin A, weight loss

Melatonin in Patients with Reduced REM Sleep Duration – (01-21-04)

December 4, 2012 by James Bogash

Melatonin in Patients with Reduced REM Sleep Duration: Two Randomized Controlled Trials

I usually hesitate to use melatonin in most cases, and would prefer valerian root and/or snacks high in tryptophan (bananas, sunflower seeds) as a first line approach. I view melatonin as a powerful hormone that has the ability to impact many aspects of physiology. However, in patients on a weird sleep schedule (midnights, travel) I have found it to work very well. Considering how many patients I see that have been given Ambien or some other such drug to sleep, the fact that melatonin induces REM sleep and Ambien doesn’t this should be a no-brainer.

JCEM — Abstracts: Kunz et al. 89 (1): 128 –

Read entire article here

Filed Under: Hormone, Sleep Apnea Tagged With: Ambien, hormone, melatonin, REM Sleep, tryptophan

HRT LOWERS RISK OF HEART DISEASE AND HOT FLASHES – (04-22-02)

November 16, 2012 by James Bogash

HRT Falls Out of Favor With Expert Committee.

Let me get this straight… Years of prescribing HRT for women in the peri and postmenopausal periods to lower risk of heart disease, osteoporosis and hot flashes based on basically shoddy research; current research showing lack of efficacy and additional studies showing downright increased risk of adverse effects such as cancer… And we need an “expert” committee to say this ain’t such a great idea??

Read entire article here

Filed Under: Hormone, Menstrual Problems Tagged With: Hormone replacement therapy, osteoporosis, Postmenopausal

GLUCOSE TO INSULIN RATIO BEST PREDICTOR OF INSULIN RESISTANCE – (08-14-03)

October 21, 2012 by James Bogash

Glucose-to-Insulin Ratio Rather than Sex Hormone-Binding Globulin and Adiponectin Levels Is the Best Predictor of Insulin Resistance in Nonobese Women with PCOS

Sorry for the long title…we are always looking for a more efficient way to evaluate insulin resistance that does not involve the arduous 3,4 or 5 post prandial glucose w/ insulin. The fasting glucose to insulin ratio is currently one of the better “snapshot” lab values for this evaluation.

JCEM — Abstracts: Ducluzeau et al. 88 (8): 3626 –

Read entire article here

Filed Under: Hormone, Insulin Tagged With: Adiponectin Levels, Globulin, Hormone-Binding, insulin resistance, PCOS

Weight Gain During Menopause–The Hard Truth

October 5, 2012 by James Bogash

It is almost a mantra for women to complain of weight gain during menopause. But are we putting the cart before the horse? Could our view be all wrong?

Before I say anything else, let me just remind everyone of that famous saying…

“Don’t shoot the messenger”

Everyone has heard a 50-something women complain about weight gain associated with menopause.  But is this just an old wives’ tale, or does menopause truly lead to weight gain in some (if not most) women?

First, let’s drop a bombshell that rarely gets discussed.

Menopause may not be related to a woman’s ovaries and their production of estrogen (specifically E2 or estradiol).

I would say that this information has the potential to blow apart the hormone replacement industry, but the news is a little late since the Women’s Health Initiative already did this when the trial was stopped early in 2002 because the data was suggesting that HRT was killing women faster then it was saving them (Wwow!  What a unique story in mainstream medicine!).

 So if it’s not the ovaries, what is it?

The adrenal glands are two small glands located just above the kidneys and, while small, have a massive role to play in our health.  In women, they are responsible for a large chunk of her circulating hormones throughout her life, NOT just post menopausally.

This means that, in a healthy functioning woman with her adrenal glands doing what they are supposed to be doing, even in the peri and post menopausal times there can be circulating levels of some hormones near to that in her youth.

Current research suggests that the adrenal glands may be critical for a healthy menopausal transition and NOT the ovaries (although the ovaries may play a role in triggering the adrenals to pick up the slack).

So why is this a problem?  Because in today’s stressed out society, our adrenals glands are beat up.  During stress, the adrenals glands do a great job of keeping up.  However, driven to work harder over the course of decades leaves them barely able to keep up with demands.

Imagine that your adrenal glands have been overworked for 30 years because you are a stress monster and spend an extra 20 minutes every morning worried about what you are going to wear before you even begin to face the trials and tribulations of the day.  They’re wiped out.

Along comes the early stages of menopause and the trigger goes out from the ovaries for the adrenal glands to pick up the slack.  Ain’t going to happen.  And you’re left with a menopausal transition rife with problems, hot flashes, bone loss and the rapid development of prediabetes.

NOT because of menopause, but because of the 30 years of abuse you’re done prior to that.  Menopause is just when it all comes crashing down.

Luckily, if you have a provider wizened enough to recognize the problem, there are solutions for adrenal problems.  Controlling stress on the front end through exercise, yoga and meditation are important.  In addition there are natural adrenal support supplements that can work very well at helping the adrenals recover from abuse.

One thing is for sure–they do not recover on their own.  They’re going to need supplemental help.

So what does all this have to do with this particular article?

Researchers looked at weight gain and menopause through the lens of the chicken and the egg.  Does weight gain precede menopause, or does weight gain happen before menopause, potentially even triggering the transition?

As I mentioned before, I’m just the messenger.

According to this study, the weight gain preceded the change in hormone levels.

If the weight gain is from menopause, this is the easier answer.  It suggests that there is little women can do; that the process is near inevitable (except for 20 years ago–then they would’ve recommended hormone replacement therapy to keep you in a horse-urine induced youth).

As with much else, the responsibility lies within us.  The good news is that means that we can make choices to improve our health and ease the transition into the postmenopausal period.

What did you find that helped with your own experience of menopause?

Filed Under: Hormone Tagged With: adrenal, adrenal fatigue, Hormone replacement therapy, HRT, menopause, perimenopause, weight gain during menopause

HRT IS COMPARED TO THALIDOMIDE IN GERMAN MEDICINE BODY – (10-15-03)

September 30, 2012 by James Bogash

Head of German medicines body likens HRT to thalidomide

Need I say more? I consider the marketing engine behind the drive for HRT right up there with the “milk it does a body good” brainwashing… What is amazing is that a prescribing pattern of gigantic proportions could be instituted and propagated for literally decades with very little data available to support its use.

bmj.com Burgermeister 327 (7418): 767

Read entire article here

Filed Under: Hormone Tagged With: German medicines, HRT, thalidomide

OXYTOCIN PLAYS A LARGE ROLE IN SOCIAL BEHAVIOR – (12-06-05)

August 20, 2012 by James Bogash

Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice

Understanding that this is a mouse study, there is an important take home message. The induction of labor with pitocin here in the US is very high. Pitocin mimics the action of oxytocin. While many may view oxytocin as the hormone that initiates and promotes labor, it also plays a large role in social behaviors. There have been numerous studies linking pitocin use and ADD/ADHD behaviors.

This study adds further support to the proposed mechanism through which this can occur.

Read entire article here

Filed Under: Hormone Tagged With: hormone, oxytocin, parturition, pitocin

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