Resistin is a hormone that worsens insulin resistance – (04-08-04)

Modulation of Resistin Expression by Retinoic Acid and Vitamin A Status

Speaking of Vit A’s bad rap…

Resistin is a hormone secreted by the fat cells that has been shown to worsen insulin resistance and overall make the obesity problem worse.

In this interesting article we see that retinoic acid (the acid form of Vit A) and Vitamin A given to mice actually lowers the genetic expression of resistin, thus improving insulin resistance and resulting in weight loss. What I would consider interesting here is that, given that Vitamin A is a fat soluble vitamin, it’s absorption would be impaired with gastric bypass surgery as well as patients will non-surgical digestion problems. Might poor digestion contribute to weight gain at least in part by reducing Vit A absoprtion? Just some food for thought…

Diabetes — Abstracts: Felipe et al. 53 (4): 882

Read entire article here

James Bogash

For more than a decade, Dr. Bogash has stayed current with the medical literature as it relates to physiology, disease prevention and disease management. He uses his knowledge to educate patients, the community and cyberspace on the best way to avoid and / or manage chronic diseases using lifestyle and targeted supplementation.