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Hormone

Medroxyprogesterone in Food Chain Raises Consternation in Europe – (07-25-02)

May 29, 2013 by James Bogash

Medroxyprogesterone in Food Chain Raises Consternation in Europe

Medroxyprogesterone is used as HRT here in the US. However, in Europe it is showing up in the feed supply in certain areas of the Netherlands and Europe is extremely concerned. What I can’t figure out is why, if this is supposedly safe for use as a hormone replacement, has Europe banned it use in life-stock and why are they so scared now that it’s shown up in the food supply for animals? Vaguely reminiscent of “flouridation” in the US, huh???…

Jul 17 – France said on Wednesday it had imported hundreds of animals, up to 200 tonnes of feed and five tonnes of meat potentially tainted with a banned growth hormone which is at the centre of a food scare spreading across Europe. Contaminated feed and animals have turned up in most of the European Union’s 15 nations since the hormone medroxyprogesterone-acetate (MPA) was discovered last month in foodstuffs at three farms in the Netherlands. The French farm ministry said 200 pigs from a suspect Dutch farm were imported to the Ain region of eastern France in July and 3.7 tonnes of ham made from them were then shipped to Italy. An additional five tonnes of suspect ham had been imported from Belgium to two companies in the Ain region and the western Ille-et-Vilaine region in Brittany, the ministry said, although it added there was no evidence the meat was tainted. “We have no proof that there has been a contamination in France, these are just products that are potentially tainted because they come from suspect farms,” a spokesman said. MPA is banned in the European Union and in other countries as a growth hormone in livestock feed. It is, however, a component in some pharmaceuticals, such as hormone replacement therapies and contraceptives. The source of the contamination has been traced to waste water from an Irish pharmaceutical factory owned by U.S. drugmaker Wyeth, Irish officials said last week. The waste was shipped to a now-bankrupt Belgian reprocessing plant, Bioland, which in turn provided glucose syrup as raw materials to Belgian soft drink makers and Dutch feed producers. The Netherlands, Germany and Belgium have been hardest hit so far by the scare over MPA. In the Netherlands, the world’s third biggest pork exporting nation, officials have found that 73 feed makers who had received tainted raw materials have delivered feed to around half of all pig producers, or around 7,000 farms. In Brussels, EU veterinary experts met on Tuesday to review the MPA contamination, a day after officials said 11 EU countries had been touched by the problem, and they stressed the need for joint action to protect public health.

Filed Under: Hormone Tagged With: HRT, Medroxyprogesterone

Non-CVD Disease Outcomes During 6.8 Years of Hormone Therapy – (07-08-02)

May 26, 2013 by James Bogash

Non-CVD Disease Outcomes During 6.8 Years of Hormone Therapy

Oops, did I forget increased risk for gallstones requiring surgery and venous thromboembolism (potentially leading to pulmonary embolism or stroke)??

Read entire article here

Filed Under: Hormone Tagged With: Hormone Therapy, Non-CVD Disease, thromboembolism

Cardiovascular Disease Outcomes During 6.8 Years of Hormone Therapy – (07-08-02)

May 26, 2013 by James Bogash

Cardiovascular Disease Outcomes During 6.8 Years of Hormone Therapy

I hate to beat a dead, crumbling dog, but I’m still confused as to why Premarin is one of the top few prescription drugs. No benefit and possible increased risk for heart disease. Increased risk for breast and endometrial cancer. Little, if any benefit on bone health. No benefit for Alzheimer’s disease. What the hell is left?? Hot flashes? Those respond very readily to phytoestrogens and progesterone cream. I’m scratching my head on this one….

Read entire article here

Filed Under: Heart Disease, Hormone Tagged With: cardiovascular disease, Hormone Therapy, Phytoestrogens, Premarin

Impaired Carotid Viscoelastic Properties with Polycystic Ovaries – (07-08-02)

May 26, 2013 by James Bogash

Impaired Carotid Viscoelastic Properties with Polycystic Ovaries

The picture of insulin resistance, polycystic ovaries, and cardiovascular disease gets clearer with each research paper. Insulin affects conversion of testesterone to estrogen via 15,20 lyase and aromatase enzymes, leading to increased levels of testesterone. The increased testosterone strongly predisposes to PCOS. On the vascular side of the picture, insulin has been shown to reduce to “stretchiness” of arteries. Here we see A=B, B=C, with research to support A=C.

Circulation — Abstracts: Lakhani et al. 106 (1): 81

Read entire article here

Filed Under: Heart Disease, Hormone Tagged With: cardiovascular disease, Carotid Viscoelastic, Polycystic Ovaries, testesterone

p53 Tumor Suppressor Down-Regulation by 17ß-Estradiol – (08-22-02)

May 19, 2013 by James Bogash

p53 Tumor Suppressor Down-Regulation by 17ß-Estradiol

The evidence continues to mount for estrogen being a carcinogen. Here we start seeing the potential biochemical reasoning for this outcome. Remember, however, that estrogen (as produced by the body) is a naturally occurring substance and serves its purpose. I firmly believe that the body, in its wisdom, down-regulates production of certain hormones as we age as a protective mechanism. Evidence strongly supports this theory for estrogen and HRT.

JCEM — Abstracts: Gao et al. 87 (8): 3915

Read entire article here

Filed Under: Hormone Tagged With: 17ß-Estradiol, carcinogen, estrogen, HRT, p53 Tumor

Role of endogenous oestrogen in aetiology of coronary heart disease – (08-12-02)

May 19, 2013 by James Bogash

Role of endogenous oestrogen in aetiology of coronary heart disease

I just hate it when research finds that estrogen, the wonder-substance of perimenopausal and postmenopausal women designed to eliminate all age related diseases and bring a woman back to her twenty-something health, really has little impact on heart disease and environmental risk factors are the major role. What a novel concept!! Imaging lifestyle changes such as exercise, healthy plant-based diets having more power to prevent disease that a prescription drug!!

bmj.com Lawlor et al. 325 (735 =9): 311

Read entire article here

Filed Under: Heart Disease, Hormone Tagged With: aetiology, Coronary Heart Disease, oestrogen

Prasterone on corticosteroid requirements of women with SLE – (08-05-02)

May 18, 2013 by James Bogash

Prasterone on corticosteroid requirements of women with SLE

This study uses DHEA (an adrogen secreted by the adrenal cortex) to lower the necessary dose of prednisone in patients with lupus. I would like to see a similar study done on patients with adrenal support designed to balance out DHEA levels. Interestingly, this study may in reality be an attempt to correct some of the imbalances created by the prednisone in the first place. Chronic corticosteriod use is known to suppress adrenal cortex function which would in turn lower DHEA levels…

Entrez-PubMed

Read entire article here

Filed Under: Hormone Tagged With: adrogen, corticosteroid requirements, DHEA levels, Prasterone

Inflammatory Biomarkers, HRT, and Incident CHD – (09-12-02)

May 18, 2013 by James Bogash

Inflammatory Biomarkers, HRT, and Incident CHD

I still continue to beat my head against the wall trying to figure out why any woman would use this stuff!! There have been no shortage of studies identifying adverse risk with HRT use (many of which HRT has been touted as benefiting for decades…). What’s even more surprising is how adamantly women talking HRT defend their use. Hot flashes and mood swings are the two most common reasons I hear. These can usually be managed very effectively with natural methods which include progesterone and some form of phytoestrogen.

Read entire article here

Filed Under: Hormone Tagged With: HRT, Incident CHD, Inflammatory Biomarkers, Phytoestrogen

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