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thromboembolism

Wyeth suppresses research on pill, programme claims – (03-26-01)

September 15, 2013 by James Bogash

Wyeth suppresses research on pill, programme claims

The third generation conctraceptive pill has been proclaimed as the “safest yet,” and yet evidence seems to be mounting that, on the contrary, the risk of thromboembolism is higher than ever before with this new pill. It appears that the manufacturers had evidence that this generation pill was producing higher risks for DVT, but the evidence was suppressed and never made it into the major medical journals. But be careful, chiropractic is dangerous and unscientific and herbal medicines will kill you.

bmj.com van Heteren 322 (7286): 571

Read entire article here

Filed Under: Miscellaneous Tagged With: chiropractic, conctraceptive pill, DVT, thromboembolism

Non-CVD Disease Outcomes During 6.8 Years of Hormone Therapy – (07-08-02)

May 26, 2013 by James Bogash

Non-CVD Disease Outcomes During 6.8 Years of Hormone Therapy

Oops, did I forget increased risk for gallstones requiring surgery and venous thromboembolism (potentially leading to pulmonary embolism or stroke)??

Read entire article here

Filed Under: Hormone Tagged With: Hormone Therapy, Non-CVD Disease, thromboembolism

Incidence of Recurrent Venous Thromboembolism After Treatment w/ Vitamin K – (06-17-03)

March 17, 2013 by James Bogash

Incidence of Recurrent Venous Thromboembolism After Treatment w/ Vitamin K Antagonists in Relation to Time Since First Event

This one is kind of an important one for me because I’ve had numerous patients in my office who have been on blood thinners for years for an isolated event many, many years ago. Basically, there doctors where afraid to take them off of the blood thinners for fear of recurrence. I remember a recent patient that had a clot in the femoral artery probably 10 years prior and had been on thinners since, with getting his blood checked every two weeks and the works. Fine and dandy, right? No future risk of stroke, right? This patient has Parkinson’s that was progressing. High dose vitamin E and ginko may protect against progression but these are no-nos with blood thinners (or so the “standard of care” would have us believe). This patient needed to have a serious heart-to-heart with his PCP and decide on his options. This study finds that after 9 months, risk from a one-time incident is negligent and blood thinners may no longer be needed.

Arch Intern Med — Abstracts: van Dongen et al. 163 (11): 1285

Read entire article here

Filed Under: Vitamins Tagged With: Antagonist, thromboembolism, Vitamin K

Hormone therapy shouldn’t be used for the heart – (11-02-00)

February 3, 2013 by James Bogash

HRT Shouldn’t Be Used as Secondary Prevention of Heart Disease

This is always a very sensitive issue with many women. I am ardently opposed to the use of synthetic drugs to “treat” a natural process in women. We have created a disease–menopause. It is a natural state of life, not one to be medicated into eradication. I do support the use of natural HRT if needed, but this constant quest for man to best nature is not good for our health. Not only does the use unquestionably increase your risk of cancer, but with the release of this study (which, ironically, has not been plastered all over the media….???) it blasts another reason many women take HRT–prevention of heart disease.

Pharmacotherapy 20(9):1021-1027, 2000 As described in the pro side of this debate, several CHD benefits are ascribed to estrogen, including positive effects on low-density lipoprotein cholesterol (LDL) and high-density lipoprotein cholesterol (HDL) and promotion of coronary vasodilatation, specifically through endothelium- dependent mechanisms, reduction of fibrinogen levels, and production of antioxidant activity. Although these are plausible mechanisms by which estrogen might provide benefit to patients with CHD, the proven benefit of hormone replacement for secondary prevention of CHD remained untested until the HERS. Hormone replacement therapy has not been proven to reduce cardiovascular events in postmenopausal women with cardiovascular disease. In contrast, it increases the risk of thromboembolism, even in a carefully screened population such as the HERS. Long-term HRT and the age of the targeted population are both associated with increased breast cancer risk.

Filed Under: Cholesterol, Heart Disease Tagged With: fibrinogen, heart disease, HRT, Lipoprotein Cholesterol, thromboembolism

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