Impaired Carotid Viscoelastic Properties with Polycystic Ovaries
The picture of insulin resistance, polycystic ovaries, and cardiovascular disease gets clearer with each research paper. Insulin affects conversion of testesterone to estrogen via 15,20 lyase and aromatase enzymes, leading to increased levels of testesterone. The increased testosterone strongly predisposes to PCOS. On the vascular side of the picture, insulin has been shown to reduce to “stretchiness” of arteries. Here we see A=B, B=C, with research to support A=C.
Circulation — Abstracts: Lakhani et al. 106 (1): 81