Which comes first? The insulin reistant chicken or the egg with abdominal fat? To a certain degree, the answer doesn’t really matter all that much because the answer (lifestyle changes) is the same in either case. But it may change the perspective on which we view the condition of obesity and diabetes. Diabetics and overweight people […]
Asymmetric Dimethylarginine, Blood Pressure, and Renal Perfusion. ADMA is still a relatively new concept. Basically, it is the arch-villian to nitric oxide. Recall that nitric oxide is a potent vasodilator and helps to lower blood pressure. When ADMA levels are high, it overrides the vasodilator effects of NO and raises blood pressure. Here we see […]
Cortisol and the metabolic syndrome in South Asians. Until the day I quit practising (or die, whichever comes first…) I will always come across patients who skip breakfast in an attempt to lose weight. And, like a robot, I go on to explain that this is probably one of the absolute worst things they can […]
Growth Hormone Replacement Therapy Induces Insulin Resistance. While this article address growth hormone as used for true deficiency states, this illustrates one of the primary dangers with many so called “anti aging” miracle supplements. Growth hormone has been big on this front for many years. However, remember that Mother Nature does things for a reason. […]
Arterial Stiffness Increases With Deteriorating Glucose Tolerance Status. More and more evidence is mounting for the contribution that insulin resistance plays in vascular dynamics, both directly and indirectly. Insulin resistance slows the breakdown of ADMA levels, thus blocking nitric oxide’s vasodilatory effects. Hyperinsulinemia lowers contractility of blood vessels. Insulin resistance increases homocysteine levels which then […]
