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insulin

Insulin Resistance and Endogenous NOS Inhibitor – (03-25-02)

March 10, 2013 by James Bogash

Insulin Resistance and Endogenous NOS Inhibitor

Insulin had long been thought of as only aiding in clearing glucose from the bloodstream, but as our knowledge base increases we see insulin as a major player in function and dysfunction in human physiology. I believe that insulin may prove to be the contributing factor in a large percentage of patients with previously diagnosed “idiopathic” or “essential” hypertension. With the evidence currently available, an patient with hypertension should be counseled in managing insulin sensitivity.

Relationship Between Insulin Resistance and an Endogenous Nitric Oxide Synthase Inhibitor.

Read entire article here

Filed Under: Insulin Tagged With: hypertension, idiopathic, insulin

Effects of Diet and Simvastatin on Lipids, Insulin, and Antioxidants – (02-11-02)

March 3, 2013 by James Bogash

Effects of Diet and Simvastatin on Lipids, Insulin, and Antioxidants

This studied evaluated the potentiating ability of a Mediterranean-type diet to a standard pharmaceutical regimine. The dietary changes in this study have some strong effects on certain risk factors for CVD. I would suggest dropping the simvastatin and adding exercise and possibly a natural cholesterol lowering compound such as garlic, niacin, policosanol or guggulipids.

Read entire article here

Filed Under: Mediterranean Diet Tagged With: CVD, insulin, lipids, Mediterranean type diet, Simvastatin

Weight Loss Exercise Plan: How Long is a Good Cardio Workout?

February 25, 2013 by James Bogash

We know that exercise is a critical part of a good cardio workout, but how much do we need? 45 minutes at least 3 times per week is the dogma we all follow.

You have to love our viewpoint here in the United States.  We don’t want to spend money on research to determine how much exercise is too much.  Nope.  We want to know just how little we have to do and still get a benefit.

Now, I’m not saying we shouldn’t be efficient with how we spend our time exercising, but this article begins to push the limits of efficiency.

For those who are patients of the clinic, read this blog regularly or have heard me speak at an event know I am a very big fan of short burst interval training.  For most, this means 30 seconds of high intensity exercise on something like a stationary bike or treadmill.  Perform 4, 6 or even 10 of these sessions with rest times in between and you have likely just met the demands for what you need to keep your heart healthy.

Most often, when I present this information to patients and groups I am speaking to, they are very happy to hear that hopping on the treadmill for 45 to 60 minutes and running through an entire album on your Walkman may be way overkill.  (Ok..so maybe it’s NOT your Walkman, but you can tell how long it’s been since I’ve been on a treadmill….).

This approach has been holding its own in the medical literature for the past few years (you can read up on the latest research in a previous article that can be read by clicking here) and I feel confident sharing this concept with others.  So, in summary, YES–5 minutes worth of actual exercise may be enough.

Keep in mind that this is NOT jogging for 30 seconds and taking a break.  This is a darn near all out burst for 30 seconds.  The rest time between sets is basically however long it takes your heart rate to return back to normal.  Overall, it’s pretty simple and could reasonably be completed in 20 minutes (shorter if your rest time improves).

But, as I mentioned in the beginning of this article, what if we could shorten this time even further?

I’m not ready to promote this as a standard approach to exercise for all of my patients, but this particular study certainly makes one ponder.  In this small study, researchers took 10 overweight or obese men and had them perform 3 2-day trials.  Here were the 3 types of exercise:

  1. None.  Full blown couch potato.
  2. 4 all out 30 second sprints, followed by 4 1/2 minute breaks.
  3. 1 single intense exercise burst, matched in the amount of calories burned in group #2 (average 198 seconds).

Sounds pretty simple as far as designs go.  So what did they find?

  • Insulin sensitivity was improved by 44.6%  in the single burst exercise compared to the couch potato.
  • There was not much of a difference in insulin sensitivity between the short burst and couch potato.
  • In the day following the interval training, fat oxidation was improved by 38%.
  • Most striking, the day following exercise fat oxidation increased by 63% in the single burst (Tweet this).

Wow.

A mere 3 1/2 minutes of straight high intensity exercise led to a huge increase in fat burning the next day.  That’s under 4 minutes and slightly more than 3 minutes.

Granted, this study was done on a group of men who were arguably out of shape to begin with, but this is likely the population that needs the most help anyway.  So I don’t know if I’m ready to cut patients down to 3.5 minutes of exercise a day, but I will definitely keep my radar up on this one.

How much do YOU exercise per day?

Filed Under: Diabetes (Type 2), Heart Disease, Insulin, Obesity and Weight Loss, Prediabetes Tagged With: Burst Exercise, Cardio Workout, Exercise Plan, Good Cardio Workouts, high intensity interval training, High Intensity Training, insulin, insulin resistance, interval training, Weight Loss Exercise Plan

Fructose Reduces Circulating Insulin and Leptin – (06-18-04)

December 30, 2012 by James Bogash

Fructose Reduces Circulating Insulin and Leptin, Attenuates Postprandial Suppression of Ghrelin, and Increases Triglycerides in Women

This has been a tough one to explain. Research has shown that fructose (as in high fructose corn syrup) has little effect on insulin levels. This would, at first glance, make it seem a-ok from a dietary standpoint. But most functional medicine practioners have recommended avoiding it for a long time now.

This article starts to shed some light on the harms of this dietary factor. Basically, fructose does not effect insulin, but it does affect leptin and ghrelin in a negative way. Lower leptin levels were seen (remember that leptin speeds up metabolism and suppresses hunger) and higher ghrelin levels (ghrelin will stimulate appretite) in the participants fed high fructose diets. This could definitely lead to weight issues.

JCEM — Abstracts: Teff et al. 89 (6): 2963 –

Read entire article here

Filed Under: Insulin Tagged With: fructose, ghrelin, insulin, leptin, triglycerides

EFFECT ON INSULIN WITH HYPERLIPIDAEMIA – (09-29-05)

July 22, 2012 by James Bogash

Effect of rosuvastatin on insulin sensitivity in patients with familial combined hyperlipidaemia

Go ahead. I know you’re on the edge of your seats. Does this statin drug positively affect one of the most devastating physiological imbalances of our time in addition to lowering cholesterol levels which are really secondary to the hyperinsulinemia that is chipping away at the very foundation of a patient’s health? Read the article. Better yet, I’ll save you the time….NO…

Read entire article here

Filed Under: Cholesterol, Insulin Tagged With: cholesterol, hyperlipidaemia, insulin, rosuvastatin

INSULIN HELPS IN PROTECTION IN MIDST OF HEART ATTACK – (09-29-05)

July 22, 2012 by James Bogash

Insulin neuroprotection against oxidative stress in cortical neurons involvement of uric acid and glutathione antioxidant defenses

Lest you think that Mother Nature created a compound like insulin and all it does is nasty things (aka Metabolic Syndrome), remember that Mother Nature does everything with a purpose. Insulin is no different. While high levels are unquestionably horrendous to our long term health, their is much evidence supporting insulin in protecting patients in the midst of a heart attack and now, with potentially lowering oxidative stress in neurodegenerative disorders. Balance is the key word.

Read entire article here

Filed Under: Insulin, Oxidative Stress Tagged With: heart attack, insulin, neurodegenerative, oxidative stress, uric acid

DESTROYING BETA CELLS OF PANCREAS PRODUCE INSULIN – (03-06-06)

June 30, 2012 by James Bogash

Dose-response relation between sulfonylurea drugs and mortality in type 2 diabetes mellitus

Ok. Let me get this straight. One of the drugs that used to be a mainstay for diabetic treatment, the sulfonylureas (such as glucotrol) actually more than doubled the risk of dying? That sounds much safer than lifestyle changes. Can’t quite figure out why this class is still on the market.

It’s also well known to ultimately destroy the beta cells of the pancreas (the cells that produce insulin), pretty much ensuring that patients on this drug would ultimately be on insulin.

Read entire article here

Filed Under: Diabetes (Type 2), Insulin Tagged With: insulin, sulfonylurea drugs, Type-2 Diabetes

ARE DIABETIC DRUGS DOING GOOD OR BAD TO THE BODY? – (01-17-05)

May 19, 2012 by James Bogash

SULFONYLUREA INDUCED BETA-CELL APOPTOSIS IN CULTURED HUMAN ISLETS

There are times when I feel I read too much medical literature. It scares me. The research on this issue started to arise about 4 years ago. We started to realize that a major class of diabetic drugs (sulfonylureas such as glyburide) actually slowly kills off the beta cells of the pancreas.

So, while they do help the blood sugar issue for a time by forcing the pancreas to produce more insulin, ultimately they are killing off these same cells. If this information does not prompt a more natural approach to diabetes, then nothing will.

Read entire article here

Filed Under: Diabetes (Type 2) Tagged With: apoptosis, diabetes, glyburide, insulin, pancreas, Sulfonylurea

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