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Stress

Adverse Effects of Modest Sleep Restriction – (06-01-04)

February 17, 2013 by James Bogash

Adverse Effects of Modest Sleep Restriction on Sleepiness, Performance, and Inflammatory Cytokines

I know I’m guilty here. We all know that sleep is very important and is a stress on the body, but to increase inflammation is definitely news to me. And considering that inflammation plays a role in just about every chronic disease we know of, getting a good night’s sleep becomes even more important. I would like to see if the use of drugs for sleep, such as Ambien, would avoid the increase in inflammatory markers since is does interfere with the deepest levels of sleep.

JCEM — Abstracts: Vgontzas et al. 89 (5): 2119 –

Read entire article here

Filed Under: Inflammation, Sleep Apnea, Stress Tagged With: Ambien, inflammation, Inflammatory Cytokines, stress

Work stress increases risk – (10-24-02)

January 29, 2013 by James Bogash

Work stress and risk of cardiovascular mortality

It is well known that chronic states of stress lead to increased cortisol levels, and this increase in cortisol wreaks havoc on most body systems. One way it does this is by increasing insulin levels, producing abdominal obesity and increasing risk of heart disease. Insomnia, difficulty focusing and hormone disruptions can also be added to the list of detrimental effects of hypercortisolemia. Anyone care to take up a collection for billboards advertsing “stress kills?”

bmj.com Abstracts: Kivimäki et al. 325 (7369): 857 –

Click here for more information.

Filed Under: Stress Tagged With: cardiovascular mortality, hypercortisolemia, stress

Adrenal support during times of stress is critical to long term ability of the adrenals – (07-02-04)

December 30, 2012 by James Bogash

Dehydroepiandrosterone and allopregnanolone protect sympathoadrenal medulla cells against apoptosis via antiapoptotic Bcl-2 proteins

Before your eyes glaze over from the long title–this one is important. DHEA and allopregnanlone are produced in part by the adrenal glands. However, under times of stress, the production goes down so the adrenals can produce more cortisol to help the body deal with the stress.

This study finds that these two compounds actually protect the cells of the adrenal gland. So–more stress means less protection to the cells that produce compounds that protect themselves. Kind of convoluted, huh? This would definitely suggests that adrenal support during times of stress is critical to long term ability of the adrenals to do their job.

PNAS — Abstracts: Charalampopoulos et al. 101 (21): 8209 –

Read entire article here

Filed Under: Stress Tagged With: adrenals, allopregnanlone, apoptosis, DHEA, stress

Prevention by lithium treatment – (03-22-04)

December 30, 2012 by James Bogash

Stress-induced structural remodeling in hippocampus: Prevention by lithium treatment

I thought this article was very interesting considering how much our approach to psychiatric disorders have shifted away from the simple approaches to a much more complicated, drug ridden approach. Lithium was used for decades as a treatment for bipolar disorder but has now fallen out of favor and replaced with new drugs that affect the central nervous system. Interestingly, lithium was also used for many years as a treatment for diabetes because of its insulin sensitizing properties. Might this protection to the hippocampal region be mediated through its effects on insulin? Incidently, many of the side effects associated with lithium treatment come from using the carbonate form, which is less bioavailable than other forms of lithium.

PNAS — Abstracts: Wood et al. 101 (11): 3973 –

Read entire article here

Filed Under: Diabetes and Obesity Tips, Stress Tagged With: bipolar disorder, diabetes, hippocampus, lithium, psychiatric disorders

Chronic stress can have some serious, negative, long term side effects – (03-29-04)

December 30, 2012 by James Bogash

Increased antigen and bacterial uptake in follicle associated epithelium induced by chronic psychological stress in rats

Okay, so we’re not all rats. But this does suggest, and common sense will tell you, that chronic stress can have some serious, negative, long term side effects.

In this study, the altered GI permeability will result in stuff getting past the GI tract into the body that should never get in. Now the immune system and liver have to deal with these invaders, and many times the liver is already overloaded from our chemical-laden lifestyles.

Gut — Abstracts: Velin et al. 53 (4): 494 –

Read entire article here

Filed Under: Strengthen Your Immune System, Stress Tagged With: antigen, chronic stress, epithelium, follicle, GI tract, Strengthen your immune system

Do Transcendental Meditation for Anxiety to Save Your Heart

December 18, 2012 by James Bogash

There are factors that play massive roles in your risk of heart disease. Stress is one factor.  Luckily, you can do Transcendental meditation for anxiety.

Stress from work.  Stress from family.  Stress from school.  It never seems to end and seems to have become ingrained in today’s hectic lifestyle.

Keep in mind that stress is a programmed protective response.  It creates underlying physiological changes that ensure our survival.  Short term it may cause the breakdown of muscle to keep a constant source of glucose in the bloodstream so that the brain has fuel and you can stay alert.  Imagine if a sabre toothed tiger was known to be in the area.  Not a good time to drop off for a nap, so you can see how the release of cortisol (the body’s stress hormone) to keep sugar in the bloodstream can keep you alive for the next few hours.

On the other hand, stress signals can be passed up the food chain.  Drought could change the grasses in the area.  Animals eating the grasses would recognize these signals within the plant and the animal’s body would respond with its own protective changes.  We then eat the meat from the animal and the message passes to us.  Our bodies may undergo adaptive changes, such as storing more calories as body fat to prepare for the coming famine.

So you can see, stress keeps us alive.  Or rather, it was designed to keep us alive when dealing with a clearly defined threat.  That does not define stress in today’s society.  Sure, when we are in a life threatening situation your body will release adrenaline and we can see how this could save your life.

But, in every other situation in today’s lifestyle does not have a clearly defined threat.  Worse, there is rarely a clearly defined end point, either.  This wreaks absolute havoc on your health.

It is possible that stress related problems are the leading cause of death in the US today.  Consider the research that finds that taking sleep medications are associated with over a half MILLION deaths per year.  While the study did not suggest this, stress can absolutely contribute to sleep problems (and is probably the leading cause of sleep disorders) and it is likely that the use of sleep medications was a marker for people who were over-stressed.  The stress is what is killing this many people per year.

If you have stress in your life, you need to rearrange your thinking.  It’s killing you and setting your kids up for health problems (read my previous blog post on this topic).  While this is not an easy solution, you need to first understand that it’s not an option. Doing otherwise IS going to kill you.  It’s that clear cut.

In the meantime, you need to manage your stress.  Exercise can be very effective.  I know that personally, for those few times that I have felt overwhelmed by stress, hiking very aggressively has always help to burn out the stress inside, leaving my problems to be faced academically, without emotional filtering.

Transcedental Meditation can be one of the most powerful tools to calm your brain.  Previous studies that I have reviewed have shown very strong protective benefits of meditation.  The pinnacle of meditation is Transcendental Meditation, or TM. 

In this particular study, participants who had heart disease (secondary prevention) were trained in transcendental meditation over the course of 12 hours of courses and followed up for a period of 5 years.  Before we go over the results, you need to understand that these patients already had problems.  Without the addition of meditation, drugs like Lipitor and blood pressure medications are usually used to try to prevent progression of heart disease and prevent death.  Frankly, they don’t do a very good job and have been trumped by much more fun interventions like dark chocolate.

So what kind of results did those who practiced Transcendental Meditation achieve?

  1. 48% overall lower risk of death. (Tweet this)
  2. 24% lower risk of dying from heart disease, having a heart procedure or being hospitalized for heart disease. (Tweet this)
  3. Those who do Transcendental Meditation according to the recommendations were more likely to survive the longest.

The bottom line is that, if you have been diagnosed with heart disease (or, frankly, if you are on your way to heart disease), taking a passive role and just using medication is going to get you half-ass results.  The ONLY way to live a long and healthy life is to make significant changes.  In the case of this study, it meant learning to manage your stress using a powerful meditation technique.

Of course, not all of us have the time and money to undergo Transcendental Meditation training.  But there are CDs, shorter online courses and biofeedback devices like the Resperate that you can take to learn skills in meditation that will dramatically benefit your health.

If you have adopted any type of stress management techniques in your life, what have you tried and what kind of benefits have you seen?

Filed Under: Heart Disease, Stress Tagged With: heart disease, meditation, Meditation For Anxiety, Mind-body Interventions, Practice Transcendental Meditation, Research On Meditation, Risks Of Heart Disease, stress, Transcendental Meditation

GINSENG BENEFITS IN MODULATION OF BODY’S RESPONSE TO STRESS – (11-03-03)

November 12, 2012 by James Bogash

Panax ginseng

Once again, American Family Physician provides an objective, complete review of a natural product. Ginseng is considered an adaptagen, meaning that is has the potential to brings things back to normal. In this case, “things” refers to the hypothalamic-pituitary-adrenal axis. Ginseng has shown benefit in modulating our body’s response to stress. Too much stress and ginseng slows the enzymes that are overworking to produce cortisol; not enough adrenal activity and ginseng speeds up the enzymes to support healthy adrenal function.

Panax ginseng – October 15, 2003 – American Family Physician.

Read entire article here

Filed Under: Stress Tagged With: adaptagen, anax ginseng, cortisol, enzymes, hypothalamic-pituitary-adrenal, stress

Obstructive Sleep Apnea: Can Sleep Disturbance Cause Seizures?

October 21, 2012 by James Bogash

Recent studies have linked sleep apnea and chronic headaches. Since migraines and seizures have similarities, can obstructive sleep apnea cause seizures?

Sleep is absolutely vital to the health of your brain.  During sleep, while our conscious mind may not be alert, this does not mean that our brain is inactive during this time. Far from it.

But sleep is not important because it allows your brain to relax, but rather because processing and healing occurs during sleep that we do not yet fully understand.  It is clear that lack of sleep is a strong trigger for those suffering from migraines and seizures.  For this reason, getting a good night’s sleep is essential for good brain health.

This task is not always as easy as it sounds for several reasons:

  1. In today’s stressed out world, chronic stress throws off normal cortisol rhythms, leading to higher cortisol levels at night, making sleep nearly impossible.
  2. Sleep apnea, both obstructive and central, make restorative sleep impossible.
  3. Our use of medications to help us sleep disrupts normal sleep patterns, potentially being linked to over half of a MILLION deaths per year.

As mentioned earlier, sleep problems have already been linked to chronic headaches and this particular study follows along these same lines as it relates to seizures.  Researchers looked at an epilepsy center and evaluated those patients with seizures for the presence of obstructive sleep apnea and found:

  1. Patients with epilepsy had a much higher incidence of OSA compared to the general population (15.2% vs. 4.41%)
  2. If patient’s seizures were well controlled, then older men with a higher seizure frequency were even more likely to suffer from obstructive sleep apnea.
  3. In those who did not have good seizure control (medically refractory), those with diabetes and snoring had a higher risk of obstructive sleep apnea.
  4. Treatment of obstructive sleep apnea with a CPAP machine in refractory epilepsy patients improved their seizure control.

Clearly there is a link between sleep problems and seizure control.  I would not be surprised at all if the hormone melatonin plays a pivotal role here.  Numerous studies over the years have linked melatonin with protecting the brain and helping with seizure control.  Sleep disturbances can be caused by a problem with melatonin production (or the timing of melatonin production) and, conversely, sleep problems can lead to altered production of melatonin in the brain.

The bottom line is that sleep is critical for normal brain health.  Whether you suffer from chronic headaches or uncontrolled seizures, sleeping has to be brought under control naturally.

The long term solution to sleep problems is stress management and exercise. Few things will restore a healthy sleep pattern as well as these two. In the short term, natural compounds like valerian root may be effective on an individual basis to calm the brain enough to allow sleep to occur naturally.

Melatonin, the hormone mentioned earlier, may also help to restore normal sleep patterns. Typical starting dosages are .5 mg an hour or so before the desired bedtime.

If you have had sleep disturbances in the past, how did you manage them?

Filed Under: Insomnia, Seizures / Epilepsy, Stress Tagged With: chronic headache, CPAP, epilepsy, melatonin, migraine, obstructive sleep apnea, seizure, sleep disturbance

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