Insulin resistance and tissue repair: A “fato-logical” phenomenon.
Wow!! If you ever had some uncertainty about what insulin resistance is than this is a great overview. Gastroenterology Online –
insulin resistance
RADIOACTIVITY AND DRUG ELUDING STENTS SLOWS RESTENOSIS – (11-03-03)
Insulin Resistance, Hyperleptinemia, and Impaired Nitric Oxide Release With In-Stent Restenosis
Many patients have been saved open heart surgery by placing a stent in a blocked artery via a vein in the leg. Unfortunately, these stents have a high likelihood of closing back up in a relatively short period. The medical profession’s approach to this has been to use radioactivity and drug eluding stents (DES) in an attempt to halt or slow restenosis. However, many natural approaches have shown good results. These include B12, folic acid and B6 supplements.
This article brings to light some other physiological conditions amenable to lifestyle changes that impact stent restensosis.
Circulation — Abstracts: Piatti et al. 108 (17): 2074.
GLUCOSE TO INSULIN RATIO BEST PREDICTOR OF INSULIN RESISTANCE – (08-14-03)
Glucose-to-Insulin Ratio Rather than Sex Hormone-Binding Globulin and Adiponectin Levels Is the Best Predictor of Insulin Resistance in Nonobese Women with PCOS
Sorry for the long title…we are always looking for a more efficient way to evaluate insulin resistance that does not involve the arduous 3,4 or 5 post prandial glucose w/ insulin. The fasting glucose to insulin ratio is currently one of the better “snapshot” lab values for this evaluation.
JCEM — Abstracts: Ducluzeau et al. 88 (8): 3626 –
HIGH PROTEIN DIET IN PREGNANCY CAUSE ELEVATED CORTISOL LEVEL IN INFANTS – (08-14-03)
Maternal High-Meat, Low-Carb Diet in Late Pregnancy: Relation to Adult Cortisol Concentrations in the Offspring
Wow. This is an interesting approach. Basically, dietary choices in pregnancy in regards to a high protein diet can pre-program the infant for future elevated cortisol levels. Elevated cortisol can lead to a major negative impact on many factors such as insulin resistance, obesity and adrenal dysfunction.
We already have many other studies that link maternal diet with pre-programming the fetus in negative ways. With today’s pregnant woman being less healthy and less attentive to good nutrition than their mothers, where will this leave us in successive generations?
JCEM — Abstracts: Herrick et al. 88 (8): 3554 –
CONTRACEPTIVE USE AND PREGNANCY COMPLICATIONS RISK TO OFFSPRINGS – (12-29-04)
ARE ORAL CONTRACEPTIVE USE AND PREGNANCY COMPLICATIONS RISK FACTORS FOR ATOPIC DISORDERS AMONG OFFSPRING?
I have mentioned repeatedly that we are programming our next generation while they are still in the womb, and research continues to support this. Couple this with lack of/shortened breast feeding, poor dietary choices and overuse of antibiotics and it’s no wonder our kids’ physiologies are screwed up. I must admit, when I first saw a link with the BCP and increased risk I was a little surprised. But, knowing that BCP contributes to insulin resistance, might this be the real pathway that the increased risk is conferred? The increased risk was 1.8 times–quite a big influence.
INSULIN RESISTANCE CAN CAUSE METABOLIC SYNDROME – (10-01-03)
The Metabolic Syndrome
Just so you don’t think I am overreacting to this “insulin resistance/metabolic syndrome” thingee I thought I would throw in yet ANOTHER article on how devastating this condition is to human health. Keep in mind that these 3 articles were all from vastly different medical journals. I say again, “There is absolutely, totally, unmistakably, NO reason for clinicians not to be evaluating for and addressing insulin resistance in every patient that walks through their door.” There is no other single intervention that could have as great of an impact from a societal level on human disease than this.
Circulation — Wilson and Grundy 108 (12): 1422
HEALTHY FOOD CHOICE MAY PREVENT PREDIABETES IN OBESE YOUTH – (10-01-03)
Prediabetes in obese youth
I hate sounding like a broken record, but this review article stresses severe insulin resistance as a major player in the deterioration of our youth’s health. While genetics plays a small role, I place this blame squarely on the shoulders of parents. Much like an overweight dog, there really is no one else to blame. The programming of a child’s genes begins in the womb, is accentuated by nursing choices (with breast feeding being number one choice) and further worsened by blatant disregard for processed sugars in the diets of our kids.
The schools do not help by trading spots in the hallways for pop machines and the “added funding” from the big companies, but these patterns are established long before the child begins school. We need to educate parents on healthy food choices.
The Journal : Back Issues
INSULIN RESISTANCE AND INFLAMMATION CAUSE OF EACH OTHER – (10-15-03)
TNF-alpha Inhibits Insulin’s Stimulating Effect on Glucose Uptake and Endothelium-Dependent Vasodilation
In English, TNF-alpha, an intracellular messenger that up-regulates many aspects of the immune system, can increase insulin resistance. This issue, to me, is beginning to look like the chicken-and-egg problem. Does insulin resistance increase overall inflammation by increasing TNF-alpha levels, or is insulin resistance caused by underlying inflammation?? Most likely the answer lies somewhere in between.
Circulation — Abstracts: Rask-Madsen et al. 108 (15): 1815