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adipose tissue

CLA reduced abdominal adipose tissue in the metabolic syndrome – (09-02-01)

September 1, 2013 by James Bogash

CLA reduced abdominal adipose tissue in the metabolic syndrome

Remember that CLA (conjugated linoleic acid) has a PPAR-gamma ligand effect, much like the new hotshot diabetes drugs (without the potential hepatic toxicity…). This study strongly supports the idea the CLA is another tool for the management of insulin resistance.

International Journal of Obesity abstract

Filed Under: Diabetes and Obesity Tips Tagged With: adipose tissue, CLA, diabetes drugs, metabolic syndrome, PPAR gamma

The OTHER Organ You May Have That You Don’t Know You Have

August 30, 2013 by James Bogash

 

Ask any high school kid to list the organs of the body and you’ll get the typical responses: Heart, liver, brain, kidneys, stomach. Maybe even an adrenal If he or she stayed awake in biology.  But some organ systems are created, not provided in the womb.

Sure, some consider the bacteria in the gut as its own organ system.  After all, it detoxifies, protects from invaders and releases hordes of chemical signals.  Despite the poor overall knowledge of this organ system, it’s not the one I’m talking about here.

This particular organ system is not present in everyone, although, unfortunately, it is present in far too large of a percentage of today’s population.

It produces a very large number of hormones that drive your risk of diabetes, heart health, inflammation and other conditions, all bad.  Worse, the weight of this organ may constitute up to HALF of your body weight.  That’s a big organ.

It’s the (or YOUR, if that’s the case) adipose tissue.  Most notably the gut.

Yes, the gut.  And you just thought it was there to keep you from checking out your toes on a regular basis.

Here’s the current theory.  The fat cells in your gut begin as extra calorie storage locations.  Adipose tissue in other areas of the body, like around the heart and thighs, although have this duty, but it’s the gut we normal point to as the greatest reservoir of extra calories.

That’s fine and dandy for a while.  Or, if you plan on hibernating and need the calories while you sleep through football season, then this is okay as well.

But gather too much extra tissue in that abdominal region and blood flow becomes an issue.  After all, the fat cells need nutrients in and waste products out as well, and if this process becomes congested, your fat cells are going to get a little upset with you.

This kick off the survival mode of your little abdominal buddy, leading to the production of hormones referred to as adipokines with names like visfatin, adiponectin and resistin.

These hormones are bad enough on their own, but there’s another problem brewing.  The adipose tissue contains a large number of stem cells, referred to as hematopoietic cells.  These cells can differentiate into immune cells that can be a major driver in inflammation.

This particular review gets a little more specific, stating that a single gram of adipose tissue can contain up to 5 million stromal vascular fraction (SVF) cells.  About half of these cells (not counting the fat cells themselves) are white blood cells.

If you do the math and the Metric to English measurement conversions, that’s an awful lot of immune cells available to affect the rest of your system.

I’ve become very adept at explaining this concept recently because our office has begun using a laser liposuction device.  Laser, from a musculoskeletal-sprain-strain-pain based standpoint, has been known for decades to lower inflammation and increase blood flow.  Kind of a perfect salve for this inflamed, hypoxic organ too many of us are carrying around our middles.  (You can read more about this laser lipo procedure by on our website by clicking here)

Overall, though, the take home message is that the lump around your middle does not just affect the way you’re going to look in that Speedo, it drives a very dangerous and damaging organ that catapults you towards chronic disease and an early death.

 

Filed Under: Inflammation, Obesity and Weight Loss Tagged With: Abdominal Fat, adipokines, adiponectin, adipose tissue, inflammation, resistin, visfatin

Extended longevity in mice lacking insulin receptor in adipose tissue – (02-03-03)

April 1, 2013 by James Bogash

Extended longevity in mice lacking insulin receptor in adipose tissue

This study looked at mice that did not have insulin receptors in adipose cells and found an 18% increase in longevity. This strongly supports previous research in mammals that suggest caloric restriction without nutrient depletion (which would result in lowered insulin levels). With more evidence arising in regards to the harmful effects of elevated insulin I am even more firmly of the belief that refined carbs are the number one factor destroying the health of Western society.

Entrez-PubMed

Read entire article here

Filed Under: Calorie Restriction, Insulin Tagged With: adipose tissue, caloric restriction, insulin receptors

Healthier fats have little relationship with our body fat – (02-04-02).

February 23, 2013 by James Bogash

Olive oil & UCP genes in rat brown adipose tissue and skeletal muscle

This article gives us an excellent opportunity to address a common misconception amongst the public.

This study, done in rats, shows that olive oil has the potential to cause the animal to burn more calories. This would point to olive oil as having a weight regulating ability. I have frequently been asked if this food or that food is “fattening.” Generally, patients think that if a food has a lot of fat, it must be fattening. This is not at all true, as we see with this study. In truth, healthier fats have little relationship with our body fat.

AJCN — Abstracts: Rodríguez et al. 75 (2): 213

Read entire article here

Filed Under: Diet Choices for Your Best Health Tagged With: adipose tissue, Skeletal Muscle

BALANCE OF VISCERAL VS SUBCUTANEOUS FAT – (04-04-05)

May 8, 2012 by James Bogash

Differential Responses of Visceral and Subcutaneous Fat Depots to Nutrients

Wow.  What an insightful approach.  Basically, visceral (bad) and subcutaneous fat have a different response in the level of release of hormones after a glucose load.  The hormones derived from adipose tissue (resistin, leptin, adinopectin, PAI-1) generally contribute to insulin resistance and obesity.  More is released by visceral fat after feeding.

So the authors have planted a seed–might checking blood levels in non-fasting states give us more insight into the balance of visceral vs subcutaneous fat?  Interesting, huh?

Read entire article here

Filed Under: Hormone, Obesity and Weight Loss Tagged With: adinopectin, adipose tissue, insulin resistance, leptin, obesity and weight loss, PAI-1, resistin

TODAY’S TREATMENT FOR INSULIN RESISTANCE IN DIABETICS ACTS ONLY IN THE LIVER – (01-21-08)

March 23, 2012 by James Bogash

Has natural selection in human populations produced two types of metabolic syndrome (with and without fatty liver)?

I have to admit, with as familiar as I am with metabolic syndrome, the concept that there may be three main clinical manifestations is new to me, but makes sense. We know that there are certain cells that make up the main contributors to insulin resistance and glucose metabolism: muscles, adipose tissue and liver. I’ve always viewed the effects as identical, but this author is suggesting that we may get 3 separate clinical pictures depending upon which tissue is most affected. Thinking about this and applying it to patients in my office, it makes much sense. I have very insulin resistant patients with very low body fat. I have patients that seem to have elevated liver enzymes long before anything else appears. And I have patients that look relatively lean but have a high body fat.

All these pictures would suggest different tissues being affected and may lead to different emphasis on treatments. Interestingly, the main drugs available today to treat insulin resistance in diabetics acts ONLY in the liver and would probably be minimally effective in the other two clinical scenarios presented here.

Read entire article here

Filed Under: Diabetes (Type 2), Fatty Liver, Insulin Tagged With: adipose tissue, diabetics, fatty liver, insulin resistance, metabolic syndrome

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