The Best Chiropractic Care in Mesa, Arizona
by James Bogash
The hormone resistin links obesity to diabetes
This is really an exciting new discovery in human health. Just a few years back the hot hormone was leptin, and the discovery of leptin helped to clarify a little further the links between insulin and body mass. It is very possibly that this new hormone, resistin, may fill in the gaps even further.
Feature of the week > Resistin diabetes
by James Bogash
Melatonin in Patients with Reduced REM Sleep Duration: Two Randomized Controlled Trials
I usually hesitate to use melatonin in most cases, and would prefer valerian root and/or snacks high in tryptophan (bananas, sunflower seeds) as a first line approach. I view melatonin as a powerful hormone that has the ability to impact many aspects of physiology. However, in patients on a weird sleep schedule (midnights, travel) I have found it to work very well. Considering how many patients I see that have been given Ambien or some other such drug to sleep, the fact that melatonin induces REM sleep and Ambien doesn’t this should be a no-brainer.
JCEM — Abstracts: Kunz et al. 89 (1): 128 –
by James Bogash
Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice
Understanding that this is a mouse study, there is an important take home message. The induction of labor with pitocin here in the US is very high. Pitocin mimics the action of oxytocin. While many may view oxytocin as the hormone that initiates and promotes labor, it also plays a large role in social behaviors. There have been numerous studies linking pitocin use and ADD/ADHD behaviors.
This study adds further support to the proposed mechanism through which this can occur.
by James Bogash
Thyroid Hormone Concentrations, Disease, Physical Function, and Mortality in Elderly Men
I recall a study several years back that dealt with the oldest old and anti-thyroidal antibodies. Now, everyone has some degree of autoimmunity to our own tissues, and this reaction increases as we get older. In that particular study, the oldest old has less autoimmunity to their own thyroid.
This study again points to the importance of healthy thyroid function in maintaining long, healthy life. So the question arises, when someone starts to experience thyroid dysfunction in their 20s, and they are put on thyroid hormone without any type of evaluation into WHY they are having thyroid problems, are we depriving them of quality of life in their later years?
by James Bogash
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
While this article is a little technical, the take home message is that vitamin D may play a strong role in defense against pathogens. The problem? Because of the induced fear of the sun (which our ancestors did not share) the levels of vitamin D deficiency in the population are nearing 75%. That’s a staggering level of deficiency for a hormone (called a vitamin, but it actually acts like a hormone) that has very important roles for our health: bone health, mental health, helping insulin do it’s job, cancer prevention, and now immune support.
by James Bogash
Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances
I know that when I hear melatonin, I used to only think of a natural hormone that can help with sleep. Now, years later, we’ve found so many other physiologic roles for melatonin. It’s a very strong antioxidant in the brain; it’s found in certain vegetables; and now, helps to regulate GI motility.
As such, in this study, 3 mg at bedtime lowered abdominal pain in patients with IBS. Interestingly, there were no beneficial effects on sleep quality. While this may not have had a bearing, I have recently moved to starting patients on a lower (.5 mg) dose to start with and this seems to result in less side effects.
by James Bogash
Effect of a high-protein breakfast on the postprandial ghrelin response
Ghrelin is a hormone that stimulates appetite. This study found that a high protein breakfast resulted in lower ghrelin levels, thus leading to higher satiety. I usually try to steer patients towards a higher protein breakfast (such as real peanut butter, high omega 3 eggs…) because these seem to keep them full longer. Unfortunately, look at what most breakfasts consist of–high glycemic index carbs that lead to earlier hunger and increased overall caloric intake through the day.
by James Bogash
Predictors of worsening insulin sensitivity in postmenopausal women
Geez. If there wasn’t the nail in the coffin of hormone replacement therapy already, this would certainly blow past that last nail and move right to cremation. Worsening insulin resistance with HRT. It’s no wonder now that we saw increased cardiovascular disease and more cognitive decline. I guess the real question is how did an intervention that was so incredibly prescribed for decades, never get a full evaluation of the potential harms before it was released? For those who think the FDA is there to protect us, this should prove this is definately not the case.
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