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B6

The Multivitamin Report You DIDN’T Hear About: 6 Important Facts

December 23, 2013 by James Bogash

The news has been a blur with recent highlights from 2 studies looking at the benefits of multivitamin use.  If you took the uneducated viewpoint, you’d throw out those bottles now.

Before I get into the gist of this article, let me point out the two articles from the Annals of Internal Medicine that were the summary of two different studies looking at the effect of multivitamin use on two different conditions.  Specifically:

  • Use of a high dose multivitamin for under 3 years to lower the risk of a SECOND heart attack.
  • Use of a standard multivitamin to protect cognitive function in older male physicians over the course of 12 years.

The use of a multivitamin in these two situations is ridiculous and were designed to fail.  Any physician who would look a patient who just had a heart attack in the eye and tell them they need to take a multivitamin to prevent a second heart attack does not understand nutrition and supplementation, especially in lieu of other lifestyle changes.  The story is not much different for the cognitive trial.  Protecting your brain is a lifetime’s task or making the right decisions, not a little over a decade of a simple, low quality multivitamin.

From these two studies, the world of medicine and the popular press have decided that multivitamins are a waste of money.

These groups however, seem unaware of this particular study.  (Special thanks for DSD International for alerting me to this study) It was a study commissioned by the Committee on Responsible Nutrition and was designed to “examine the potential health care cost savings if people over the age of 55 use certain dietary supplements that have been shown to lower disease risks. Specifically, this report will examine evidence that demonstrates that the use of key dietary supplement ingredients can reduce illness-related hospital utilization costs associated with heart disease, age-related eye disease, diabetes, and bone disease in the United States.”

The 125 page report goes into detail about the relationship between specific supplements and specific diseases.  Here’s a summary:

  1. The use of omega-3 supplements to lower risk for those at higher risk of heart disease can save as much as $2.06 billion on average per year.

  2. The use of folic acid, B6, and B12 to lower risk for those at higher risk of heart disease can save as much as $1.52 billion per year.

  3. The use of phytosterol containing supplements in all U.S. adults over the age of 55 diagnosed with heart disease can save as much as $4.23 billion per year.

  4. The use of lutein and zeaxanthin supplements in every person over the age of 55 with age-related eye disease (ARED like macular degeneration) can save $966.6 million per year.

  5. The use of calcium and vitamin D by all U.S. women over the age of 55 diagnosed with osteoporosis can save $1.52 billion per year.

  6. The use of magnesium in these same osteoporotic women can save $595.3 million per year.

These are some serious numbers AND take into account the cost of the supplementation, which is minute compared to the cost of drugs designed for these same conditions.  Side effects, as well, are minimal, again especially when compared to the drugs used to treat these conditions.

The bottom line is that, before you run to the cabinet to throw out your supplements, you should consider what happens when we study conditions that supplements actually make sense to use against, instead of waste-of-money studies that don’t even make sense.

 

Filed Under: Vitamin B12, Vitamin D, Vitamins Tagged With: B12, B6, Folic Acid, Lutein, multivitamin, Vitamin D, Zeaxanthin

Low Vit B6 Associated w/ Risk of Deep-Vein Thrombosis – (11-19-01)

August 11, 2013 by James Bogash

Low Vit B6 Associated w/ Risk of Deep-Vein Thrombosis

This is a very interesting finding that links DVTs and low plasma B6. What is interesting to note here is that the birth control pill is well known for depleting the body of B6, and that all generations of BCP increase risk of DVT. It may be that this depletion of B6 is the mechanism by which this side effects occurs.

Circulation — Abstracts: Cattaneo et al. 104 (20): 2442

Read entire article here

Filed Under: Vitamins and Supplements 101 Tagged With: B6, BCP, DVTs

S-adenosylhomocysteine more sensitive for CVD than homocysteine (11-29-01)

August 11, 2013 by James Bogash

S-adenosylhomocysteine more sensitive for CVD than homocysteine

Remember where you heard it first!! The laughable part of this is that few physicians have accepted homocysteine as a risk factor for CVD (and lowering therapies with Vit B12, B6 and folic acid) and yet the rest of the research field is moving on to bigger and better stuff. Just accept that mainstream medicine is typically several decades behind the research and move on.

AJCN — Abstracts: Kerins et al. 74 (6): 723

Read entire article here

Filed Under: Heart Disease Tagged With: B6, CVD, Folic Acid, homocysteine, S-adenosylhomocysteine, Vit B12

Higher Estrogen Linked to Decreased Homocysteine – (08-17-00)

June 27, 2013 by James Bogash

Higher Estrogen Linked to Decreased Homocysteine

This may be one of the routes by which estrogen is known to lower risk of heart disease. Of course, supplementing with folic acid, Vit B12 and B6 will also lower levels of homocysteine WITHOUT increasing your risk of breast and endometrial cancer.

Am J Epidemiol 2000;152:140-148 Data from the Third National Health and nutrition Examination Survey (NHANES III) indicate that estrogen status is inversely related to total homocysteine concentration, a risk factor for vascular occlusion. “Perhaps supplementation with estrogen would be beneficial to women by lowering their homocysteine concentration and thereby lowering their risk of heart attack and stroke,” Dr. Morris said. But, she cautioned, “this was a descriptive study, so one cannot draw clinical conclusions about the benefits of estrogen supplementation.”

Filed Under: Cancer Tips, Heart Disease, Hormone Tagged With: B6, endometrial cancer, estrogen, heart disease, homocysteine, Vit B12

Homocysteine Levels and the Risk of Osteoporotic Fracture – (06-10-04)

February 17, 2013 by James Bogash

Homocysteine Levels and the Risk of Osteoporotic Fracture

Now that homocysteine is a well established risk factor for heart disease, the research community is moving on to other things homocysteine may contribute to. Remember the homocysteine may just be a marker for altered methylation ability, which is a process aided by Vit B12, B6, riboflavin, SAM-e, betaine and folic acid that is integral to the proper cell division of every single cell and well as the protection of DNA and the production of some neurotransmitters.

So, defects in the homocysteine pathway (which are very susceptible to genetic uniqueness’s  can lead to a wide variety of downstream conditions. The bottom line–interventions designed to lower homocysteine levels would probably benefit most patients and be cheaper than checking blood levels.

NEJM — Homocysteine Levels and the Risk of Osteoporotic Fracture.

Read entire article here

Filed Under: Osteoporosis Cures and Bone Health Tagged With: B6, heart disease, homocysteine, Methylation, osteoporotic, Vit B12

VITAMIN B12 AND B6 RISK FOR PARKINSON DISEASE – (12-04-06)

July 30, 2012 by James Bogash

Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease

Some interesting findings in this study. First of all, they looked at dietary intake, NOT supplements, and found that higher levels of B6 were very protective for Parkinson’s (decreased risk over 50%), but ONLY in smokers. Don’t ask me yet what the mechanism of this protection is, but I’m sure we’ll have an answer in another 10 yrs or so..

Read entire article here

Filed Under: Parkinson's, Vitamin B12 Tagged With: B6, Dietary folate, Parkinson, Vitamin B12

WHAT ARE THE PROBLEMS WITH INCREASED FOLIC ACID? – (02-13-06)

May 26, 2012 by James Bogash

Unmetabolized Folic Acid in Plasma is associated with Reduced Natural Killer Cell Cytotoxicity among Postmenopausal Women.

Given that I am a big fan of folic acid supplementation, articles like this do cause me to slow down an re-evaluate what I’m doing. A few things to consider. Some supplements do use the form 5-tetrahydrofolate, which is the converted form, which is not a bad idea. However, you can run into problems when a patient is loaded up on folic acid (such as with food fortification) but not given adequate levels of B12 to go with it.

These two, along with betaine and B6, run in the same circles. So, if one is going to consider supplementation of folic acid, there needs to be an adequete level of B12 given. This is NOT found in pharmaceutical prenatals, which have very low levels of B12.

Read entire article here

Filed Under: Vitamin B12 Tagged With: 5-tetrahydrofolate, B12, B6, cytotoxicity, Folic Acid, food fortification

WHILE EVALUATING FOR CARDIAC RISK CHECK HOMOCYSTEINE LEVELS – (01-17-05)

May 19, 2012 by James Bogash

NUTRITION AND ABERRANT DNA METHYLATION PATTERNS IN ATHEROSCLEROSIS: MORE THAN JUST HYPERHOMOCYSTEINEMIA?

I just love situations like this. Basically, mainstream medicine is just beginning to embrace the idea that maybe we should check homocysteine levels when evaluating for cardiac risk. And I have notice over the years that more and more people that attend my seminars are aware of homocysteine. Some still fight with their PCPs to get the test ordered. So here we are, now looking for factors that are even more fundamentally important than homocysteine.

The authors of this review acknowledge that elevated homocysteine coupled with inadequate levels of methylation factors (such as folic acid, B12, B6, SAMe…), but feel that there is yet a more basic alteration at the nutritional levels that occurs that makes the arteries more susceptible to damage from homocysteine. Stay tuned..

Read entire article here

 

Filed Under: Heart Disease Tagged With: atherosclerosis, B12, B6, cardiac risk, Folic Acid, homocysteine, methylation factors, SAMe

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