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Colon / Colorectal Cancer

Stimulation of Cdx2 homeobox gene by butyrate in colon cancer – (03-14-02)

March 10, 2013 by James Bogash

Stimulation of Cdx2 homeobox gene by butyrate in colon cancer

While the title may be a little technical, this is additional support on the benefits of a combination of soluble fiber and probiotics on intestinal health and cancer prevention. Remember that friendly bacteria in the gut digest the soluble fiber to produce short chain fatty acids, one of which is butyrate. Personally, I think the media did a tremendous disservice by sensationalizing the results of one trial that did not show a benefit of fiber in colon cancer. Of course, the media did not mention that the study did not examine intestinal flora nor did they differentiate insoluble fiber from soluble.

Gut — Abstracts: Domon-Dell et al. 50 (4): 525

Read entire article here

Filed Under: Colon / Colorectal Cancer Tagged With: Butyrate, cancer prevention, colon / colorectal cancer, probiotics

LOWER LEVEL OF GROWTH HORMONE HAS LESS RISK OF COLON CANCER – (04-15-02)

November 16, 2012 by James Bogash

Polymorphism in the Human GH1 Gene and Colorectal Cancer

One of the theories in mainstream medicine is that, if an young rat has higher levels of something than an old rat, then that must be why the old rat is old. We use this convoluted thinking to support hormone replacement therapy and certain “anti-aging” wonder supplements such as human growth hormone.

This study shows that a group of people with a genetic defect that results in lowered levels of growth hormone have a reduced risk of colon cancer. This does lend support to the “more is better” not being better….

Cancer Spectrum: Le Marchand et al, pp. 454-460.

Read entire article here

Filed Under: Colon / Colorectal Cancer Tagged With: colorectal cancer, growth hormone, Polymorphism

Black, Green and White Tea Benefits vs Water Health Benefits

November 15, 2012 by James Bogash

You subscribe to the dogma that you need 8-10 glasses to get water health benefits. You know white tea benefits also are strong. But how do the two compare?

I was speaking to a group of employees at one of the local casinos today on the topic of diabetes and prediabetes.  Of course, no topic related to diabetes would be complete without discussing the evils of Bisphenol A (BPA) from plastic water bottles.  Unfortunately, pretty much everyone had a plastic water bottle from the lunch offerings.  I hate to be such a killjoy.

I always strongly advocate tea drinking anywhere that I can while at the same time steering people aware from drinking out of plastic water bottles. As I’ve mentioned time and time again, there is a shocking lack of evidence for the “8-10 glasses of water per day” mantra that we seem to hear from every group giving health recommendations. Based on these recommendations, one would think that we are all merely 16.3 fluid oz of water away from drying up into a husk and blowing away.

Inevitably, someone in the crowd today asked about whether tea counts towards our water intake per day. I mean–hasn’t everyone heard that caffeine dehydrates us and we need to drink MORE water to make up for the tea drinking?

Let’s look at this a little more closely and compare the tea vs water debate.

On one side, we have the 8-10 glasses of water per day camp. The research to back up this claim?  Pretty much nil.  We do however, have loads of studies linking BPA exposure to obesity, diabetes and breast cancer. There is, of course, the whole environmental / landfill argument from all that plastic garbage. Then we have reports from the Environmental Working Group (EWG.org) that demonstrate that much of the popular bottled water brands are little more than tap water that is far to high in pollutants to be consumed by pregnant women in the state of California. Another recent study found a slight increase in diabetes risk with drinking more than 6 glasses of water per day.

Not looking too good for water so far.

On to tea.

  • Reduces diabetes risk
  • Protects our brain
  • Protects our heart from damage
  • Lowers blood pressure
  • Lowers ovarian cancer risk
  • Lowers breast cancer risk

The list could actually be quite longer, but I’m sure you’re getting the point.

The answer would be–why on Earth would you want to add water to compensate for the tea you’re drinking? In these studies above, the participants were not drinking tea AND water–they were drinking tea.

And, just in case all of the above is not convincing enough, this particular study looked at how much drinking tea protected against digestive system cancers (gastric, colon). On average, drinking tea lowered overall risk by 14%. The more tea someone drank and the longer they had been drinking tea, the greater the protection. This climbed to a 26% lower risk in those who drank 2-3 cups per day.

Most of the intake was in the form of green tea, but overall, I usually tell patients that whatever black tea does, green tea does better, and what green tea does, white tea does better. Personally, we go through so much tea at our house that we drink all kinds, looking more for taste than type of tea.

To get a better idea how my household makes tea, refer to an older blog post here that describes how we make it.

Do you have a favorite brand or type of tea?

Filed Under: Colon / Colorectal Cancer, Gastric Cancer Tagged With: black tea, colon / colorectal cancer, colorectal cancer, drinking tea, Gastric Cancer, green tea, white tea

RISK OF COLON CANCER WITH INCREASED LEVEL OF OX-LDL – (12-09-04)

September 15, 2012 by James Bogash

OXIDIZED LOW-DENSITY LIPOPROTEIN LEVELS AND RISK OF COLORECTAL CANCER

I have always stood by the concept that LDL cholesterol does not do damage to us until it gets damaged. However, what if the oxidized LDL (ox-LDL or oxysterols) are merely a marker for the amount of inflammation, and that the increased oxidative stress from the increased inflammation is actually the real culprit? Here we see an increased risk of colon cancer with an increasing level of ox-LDL, with greater than a three fold increase with the higher levels. Serum Oxidized Low-Density Lipoprotein Levels and Risk of Colorectal Cancer: A Case-Control Study Nested in the Japan Collabo..

Read entire article here

Filed Under: Colon / Colorectal Cancer Tagged With: colon / colorectal cancer, colorectal cancer, inflammation, LDL cholesterol, oxidative stress, oxidized LDL

DIETARY PATTERNS RISKS COLORECTAL CANCER IN WOMEN – (02-17-03)

September 15, 2012 by James Bogash

Major Dietary Patterns and the Risk of Colorectal Cancer in Women

This falls into the “how much did we pay for this??” study. What chronic disease does a Westernized lifestyle NOT increase your risk for??

Major Dietary Patterns and the Risk of Colorectal Cancer in Women

Read entire article here

Filed Under: Colon / Colorectal Cancer Tagged With: chronic disease, colorectal cancer, Major Dietary Patterns

BIA ANALYSIS IMPLIES PROGNOSIS IN ADVANCED COLORECTAL CANCER – (12-15-04)

September 15, 2012 by James Bogash

BIOELECTRICAL IMPEDANCE PHASE ANGLE IN CLINICAL PRACTICE: IMPLICATIONS FOR PROGNOSIS IN ADVANCED COLORECTAL CANCER.

Given that I use BIA analysis quite frequently in my practice, this one hits home. It’s just kind of funny how some patients and physicians react to the BIA and the phase angle that is calculated by the BIA. Most probably think it’s more hype and voodoo than reality. Unfortunately, this is not the case, and phase angle tracks closely with mortality in many disease states.

This study shows a cutoff at 5.57 (higher is better). Those higher than this had an average mortality of 40.4 months. Under? 8.6 months. Almost five times longer. Pretty good predictive value for voodoo…

Read entire article here

Filed Under: Colon / Colorectal Cancer Tagged With: BIA, colorectal cancer

IS CURCUMIN PROTECTIVE – A SPICE FOUND IN CURRIES? – (02-21-05)

May 12, 2012 by James Bogash

Consumption of Chemopreventive Agent Curcumin by Cancer Patients

The idea that curcumin (a spice found in curry and mustard) was protective is not a big surprise.  What I found definately surprising was that, while the curcumin given to the colorectal cancer patients was found in the tumor and found to lower the amount of damage being done to the DNA, it was not seen in the bloodstream.

So, the question here is, was all the curcumin out of the bloodstream before one hour had elapsed, or did the curcumin not even get absorped effectively?  I don’t have the answer, but given how frequently curcimin is put into “anti inflammatory” formulas for conditions such as joint pain it makes me wonder if the curcumin is even making it to the target tissues.

Read entire article here

 

Filed Under: Cancer, Colon / Colorectal Cancer Tagged With: cancer, Chemopreventive Agent, colorectal cancer, Curcumin

CONSUME FRUITS AND VEGETABLES TO REDUCE RISK OF COLORECTAL CANCER – (12-03-07)

April 21, 2012 by James Bogash

Dietary Flavonoids and the Risk of Colorectal Cancer

I’ve said many times before that one of the reasons I do not support our national organizations is that they spent very minimal time on prevention and consistently preach about finding a cure. The bottom line is that we have so many opportunities to prevent many types of cancer that they should essentially not be present in our society, let alone a major killer. But the appropriate details never seem to get out to the general public. The most specific we ever get is “eat your fruits and vegetables.” Hardly specific. Knowing which fruits and veggies pack the strongest punch can help.

This article reviews the effect of a variety of flavonoids on colon cancer and found that the risk reduction could be as high as 32% for quercitin (high in onions) and catechins (high in teas). This is with one single intervention. Add in vitamin D, exercise, high fiber coupled w/ healthy bacterial flora, etc, and you’ve pretty much eliminated all but the most tough cases.

Read entire article here

Filed Under: Colon / Colorectal Cancer Tagged With: catechins, colon / colorectal cancer, colorectal cancer, exercise, flavonoids, high fiber, quercitin, Vitamin D

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