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oxidized LDL

CRP binds both oxidized LDL, apoptotic cells through common ligand – (09-26-02)

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CRP binds both oxidized LDL, apoptotic cells through common ligand

CRP is now widely accepted as an independent risk factor for heart disease (at least it is by those of us that don’t rely on the drug companies as a sole source of continuing medical information….), but whether it was a marker or played a direct role was unknown. This article begins to identify CRP as playing a direct role. I have seen interventions such as exercise and avoidance of refined carbs lower CRP levels dramatically.

Chang et al., 10.1073/pnas.192399699

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CARDIAC STENT VS OPEN HEART SURGERY – (07-16-04)

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Percutaneous Coronary Intervention Results in Acute Increases in Oxidized Phospholipids and Lipoprotein(a)

While there is no question that, should I have a choice between PCI and open heart surgery, I would pick PCI anyday. But this procedure is done on many patients as a screening tool with chest pain. Many negative tests are done without thought to the long term consequences other than healing of the incision.

This study finds that there is a long term elevation of oxidized LDL (remember–LDL cannot damage our vessels until it gets damaged via oxidation) after PCI. This might be a willing trade off to the patient that avoided open heart surgery. But to the patient that was scoped to “rule out” obstructive lesions, this is not a good trade off. Maybe these findings will push a greater use of the non-invasive ultra fast CT, which does a nice job of ruling out cardiac involvement in patients with chest pain. Circulation — Abstracts: Tsimikas et al. 109 (25): 3164 –

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RISK OF COLON CANCER WITH INCREASED LEVEL OF OX-LDL – (12-09-04)

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OXIDIZED LOW-DENSITY LIPOPROTEIN LEVELS AND RISK OF COLORECTAL CANCER

I have always stood by the concept that LDL cholesterol does not do damage to us until it gets damaged. However, what if the oxidized LDL (ox-LDL or oxysterols) are merely a marker for the amount of inflammation, and that the increased oxidative stress from the increased inflammation is actually the real culprit? Here we see an increased risk of colon cancer with an increasing level of ox-LDL, with greater than a three fold increase with the higher levels. Serum Oxidized Low-Density Lipoprotein Levels and Risk of Colorectal Cancer: A Case-Control Study Nested in the Japan Collabo..

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LDL PARTICLES CAUSE DAMAGE TO VESSEL WALLS – (07-25-05)

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Oxidized LDL induces mitochondrially associated reactive oxygen/nitrogen species formation in endothelial cells

We’re back to my future book “Mitochondrial dysfunction as the root of all chronic disease.”  Not quite sure if that title is going to catapult the book to the New York Times bestseller list, though.  Anyway, I have mentioned many times before that cholesterol does not do damage to our vessels until it gets damaged, usually through inflammation or oxidative stress.

Now we are starting to identify the pathway by which this oxidized LDL particle creates damage to the vessel wall.  And guess what comes to the forefront.  You guessed it–mitochondrial induced oxidative stress.  Mammalian health and disease is such an incredible, connected labyrinth.

So, natural approaches to lower the risk of CVD.  Do they act by protecting the LDL molecule or protecting the mitochondria from initiating the damage caused by oxLDL?  Most likely the answer is both.

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