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Cholesterol

Markers of cumulative biological risk: studies of successful aging – (05-10-01)

September 10, 2013 by James Bogash

Markers of cumulative biological risk: studies of successful aging

This article reviews the use of allostatic load (AL) to determine biological risks of aging. AL is an index that uses 10 parameters of biological functioning to give an overall level of risk. I have seen computer programs that attempt to give a biological age to the patients. I have very little faith in these because they do not address real questions (they ask for seat belt use, check BP and cholesterol, exercise levels…). Ironically, none of the 10 factors in AL are used on these questionnaires. I have to mention one more thing for those of you that just read my comments…6 of the 10 factors are associated with Syndrome X. Go figure…a disease state that most of the medical profession is unaware of, a disease state that is highly modifiable with nutrition and natural medicine, and one that contributes to 60% of aging? And we wonder why medicine in the US is ranked so poorly.

PNAS — Abstracts: Seeman et al. 98 (8): 4770

Read entire article here

Filed Under: Anti-Aging, Cholesterol Tagged With: Aging, allostatic load, BP, cholesterol

Cholesterol from eggs increases the ratio of total cholesterol to HDL – (05-28-01)

September 5, 2013 by James Bogash

Cholesterol from eggs increases the ratio of total cholesterol to HDL

It is very likely that all the press about eggs being fine for cholesterol levels was promoted and propelled by the egg industry. I’ve never been a great fan of eggs and this does have a tendency to solidify my opinions. However, egg whites are a very good source of high quality protein, along with whey, soy and certain rice proteins. If you do like eggs, try to eliminate the yolks and keep the whites.

AJCN — Abstracts: Weggemans et al. 73 (5): 885

Read entire article here

Filed Under: Cholesterol Tagged With: cholesterol, eggs, HDL

Dietary cholesterol is secreted over several subsequent meals – (05-28-01)

September 5, 2013 by James Bogash

Dietary cholesterol is secreted over several subsequent meals

This is truly a insightful article that may help us better understand how the food we take in can affect our overall health days after we eat. These researchers determined that, when the participants ate cholesterol, it took up to 48 hours for that cholesterol to show up in the bloodstream. Each successive meal “pushed” the cholesterol from the original meal into the bloodstream. This study shows that dietary constituents do not always show up directly in the bloodstream. Too many times mainstream medicine does not look beyond the most immediate meal.

AJCN — Abstracts: Beaumier-Gallon et al. 73 (5): 870

Read entire article here

Filed Under: Cholesterol Tagged With: bloodstream, cholesterol

Elderly show severe impairment of DHEA-S – (08-27-01)

September 1, 2013 by James Bogash

Elderly show severe impairment of DHEA-S

Given the number of articles appearing related to the topic of adrenal function, a quick review is in order. The medulla (inside) of the adrenals produce epinephrine and norepinephrine…key players in the adrenaline response. The cortex (outside) produce three hormones from cholesterol…aldosterone (regulates blood pressure), cortisol (the body’s stress hormone) and DHEA (which goes on to ultimately become estrogen and testosterone). In the body’s initial response to stress, the body will produce more cortisol at the expense of DHEA (a phenomena known as pregnonolone steal…). Chronic stress will result in both lowered cortisol and DHEA…basically the adrenals “poop out.” All these levels are easily, safely and accurately measured with salivary testing. Synergy : Clinical Endocrinology 55 (2), 259-265

Read entire article here

Filed Under: Cholesterol Tagged With: cholesterol, cortisol, DHEA-S, epinephrine, norepinephrine, testosterone

Had a Rotator Cuff MRI? 4 Things to Know Before Surgery

August 23, 2013 by James Bogash

There are times when I wish MRI and CT scans were never invented.  I can’t tell you how many times I’ve had to explain to patients that what was found on the MRI that his or her PCP ordered has absolutely nothing to do with the pain currently experienced.

Low back, knees and shoulder seem to be the worst.  I certainly have ranted in the past about the massive overuse of technology and medical imaging in medicine today.  As strange as it may be, the pathway is very clear:  Having a MRI makes that person more likely to undergo  epidurals and surgery.  Having an epidural leads to surgery as well.  So, unless you’re willing to go under the knife, don’t even consider an MRI.  The ONLY time to order advanced imaging is when your provider thinks that there is a high likelihood that the information obtain will make an important change in your treatment plan.

Imaging is not used just to confirm what a physician has already determined.  It’s really not that hard to determine if someone has a disc problem or if someone with advanced arthritis is dealing with spinal stenosis.  If signs point to a disc problem, why on Earth would you waste the time and resources to order an MRI at that point?  Just treat the condition as if it’s a disc (which, in our office, would involve flexion / distraction technique).

Now, if you don’t respond within expected timeframes (30 days is a safe bet) or if your condition worsens while getting treatment, then imaging becomes more important to see if some underlying factor is affecting your response to treatment.  Our office is pretty conservative when it comes to ordering advanced imaging.  I’d say that I personally order an MRI less than a handful of times per year.  However, it seems like at least this same number of times each month we’re requesting the results of an MRI or CT scan that was ordered by another provider and probably shouldn’t have been.

This is when I have to battle against the perception that a MRI or CT scan is exact and answers all questions.  Far too often, a MRI comes back with some type of disc bulge, and yet the patient has absolutely no signs that a disc is involved in his or her condition.  Only rarely does an MRI ordered by another provider come back with valuable information that changes the treatment we’re doing in the office.

All this would be fine if MRIs and CTs didn’t come with significant problems beyond the cost.  CT scans, despite still being handed out like candy (had a patient in yesterday whose son was given a head CT recently in the ER when an MRI would have been a better choice to look at the brain) have a tremendous amount of radiation exposure associated with them and have been linked to some 14,500 cancer deaths per YEAR.  MRIs, as mentioned, begin the dangerous pathway towards more invasive treatment measures and surgery.

All of this brings us back to this particular study.  Researchers looked at a group of postmenopausal women with NO shoulder pain and compared them with premenopausal women with no shoulder pain to see what there rotator cuffs looked like in an MRI.  Here’s what they found:

  1. 8.9% had full-thickness tears (mainly localized in the supraspinatus tendon of the dominant side) in the postmenopausal group.
  2. Non-painful, full thickness tears in the premenopausal group was 3.1%.
  3. Women with tears were more likely to have higher BMI, higher fasting glucose and lower HDL cholesterol.
  4. Overall, higher BMI and lower levels of HDL cholesterol increased the risk of having a tear.

Wow!  Quite a few take home messages.  First, we need to see that a decent size chunk of females, both pre and postmenopausal, have complete thickness rotator cuff tears that are painless.  I can’t tell you how important that little factoid is.  Just because you see a tear on a MRI does NOT mean that this is the problem.

Second, lifestyle choices (as evidenced by cholesterol and BMI relationships) played a large role in the tendon damage.  This isn’t really hard to envision since tissue healing and inflammation are going to be effected by the choices we make.

So, just because you have shoulder pain does NOT mean that you need to have an MRI (and X-rays are just short of worthless for shoulders anyway…) unless you have failed a course of conservative care, which, in my clearly biased opinion, would involve a chiropractor who does advanced soft tissue techniques…

Filed Under: Cholesterol, Shoulder Pain Tagged With: rotator cuff MRI, rotator cuff surgery, rotator cuff tear, shoulder MRI, shoulder pain

Efficacy of Concentrated n-3 Fatty Acids in Hypertriglyceridaemia – (05-14-01)

August 19, 2013 by James Bogash

Efficacy of Concentrated n-3 Fatty Acids in Hypertriglyceridaemia

This study compares one pharmaceutical preparation for lowering lipids vs fatty acids and finds Gemfibrozil more effective. However, we are once again try to take a piece of natural medicine and trying to fit it into the Western medicine mold. Instead of just n-3 fatty acids (which I would rather see patients get from fish and nuts instead of a supplement), I would add exercise, limited soy products, probiotics, avoidance of refined carbs….The approach goes on and on. I would love to start seeing comparisons of approaches, not tools.

Clin Drug Invest 21(3):175-181, 2001 Our study indicated that both n-3 fatty acids and gemfibrozil markedly decreased TG levels in patients with severe hypertriglyceridaemia. Gemfibrozil, however, decreased TG levels and increased HDL-C significantly more than n-3 fatty acids.

Filed Under: Cholesterol Tagged With: Gemfibrozil, Hypertriglyceridaemia, n-3 Fatty Acids, probiotics

Cocoa and dark chocolate on LDL oxidative susceptibility – (11-08-01)

August 17, 2013 by James Bogash

Cocoa and dark chocolate on LDL oxidative susceptibility

Great news for chocalate lovers!! It does appear that the polyphenols in chocolate do have some protective effects. However, this article does not take into effect the affect of stearic acid in the chocolate that are believed to have adverse effects of lipids.

AJCN — Abstracts: Wan et al. 74 (5): 596

Read entire article here

Filed Under: Cholesterol Tagged With: dark chocolate, LDL oxidative, polyphenols, Stearic acid

Elevating HDL in Mice Remodels Advanced Atherosclerotic Lesions – (11-19-01)

August 11, 2013 by James Bogash

Elevating HDL in Mice Remodels Advanced Atherosclerotic Lesions

This is an interesting concept that needs to be followed up on. This study suggest that HDL cholesterol actually has the potential to begin to clean up some of the plaguing in arteries. This would be a remarkable achievement, and would definitely impact cardiac surgeries and procedures as well as further support the work of Dr. Dean Ornish in reversing heart disease. Remember that the medication used to lower LDLs but has a relatively small impact on raising HDL. On the other hand, exercise, monounsaturated fats (i.e. olive oil…), niacin and phytoestrogens can increase HDL levels safely.

Circulation — Abstracts: Rong et al. 104 (20): 2447

Read entire article here

Filed Under: Cholesterol, Heart Disease Tagged With: arteries, atherosclerotic lesions, HDL, heart disease

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