LifeCare Chiropractic

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Polycystic Ovary

TNF Receptor 2 Gene and Polycystic Ovary, Hyperandrogenism – (08-22-02)

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TNF Receptor 2 Gene and Polycystic Ovary, Hyperandrogenism

We’re getting into some heavy biochemistry here, but the concept is similar to those in past Updates. We are starting to identify genetic polymorphisms (SNPs) that can affect our body’s response to our environment. Here we see a genetic variant in a receptor for TNF-alpha. Recall that TNF-alpha upregulates our immune system and blockade of its action is a new therapeutic target in diseases such as rheumatoid arthritis and Crohn’s disease. With the genotype in this study, patients were shown to have increased risk for PCOS and hyperandrogenism. Aggressive natural approaches to TNF-alpha lowering in these patients (managing insulin resistance, exercise…) may yield better outcomes or even prevention.

JCEM — Abstracts: Peral et al. 87 (8): 3977

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Metformin on Early Pregnancy Loss in the Polycystic Ovary – (02-11-02)

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Metformin on Early Pregnancy Loss in the Polycystic Ovary

I think this is somewhat of a landmark article. Not that the concepts are, but to see them all together is always exciting. A few interesting things here. First, using metformin, which increases insulin sensitivity, can dramatically drop the risk of miscarriage in patients with PCOS. PCOS has been linked strongly with hyperinsulinemia and this would be a natural progression from there. Interestingly, the standard OB/GYN approach the PCOS is the birth control pill, which is well documented to increase insulin resistance. Go figure that one out!! And, of course, instead of metformin I would rather see a program of exercise, whole grain instead of refined carb intake, and supplementation with chromium, vanadium and possibly CLA.

JCEM — Abstracts: Jakubowicz et al. 87 (2): 524

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