TNF Receptor 2 Gene and Polycystic Ovary, Hyperandrogenism – (08-22-02)



TNF Receptor 2 Gene and Polycystic Ovary, Hyperandrogenism

We’re getting into some heavy biochemistry here, but the concept is similar to those in past Updates. We are starting to identify genetic polymorphisms (SNPs) that can affect our body’s response to our environment. Here we see a genetic variant in a receptor for TNF-alpha. Recall that TNF-alpha upregulates our immune system and blockade of its action is a new therapeutic target in diseases such as rheumatoid arthritis and Crohn’s disease. With the genotype in this study, patients were shown to have increased risk for PCOS and hyperandrogenism. Aggressive natural approaches to TNF-alpha lowering in these patients (managing insulin resistance, exercise…) may yield better outcomes or even prevention.

JCEM — Abstracts: Peral et al. 87 (8): 3977

Read entire article here

James Bogash

For more than a decade, Dr. Bogash has stayed current with the medical literature as it relates to physiology, disease prevention and disease management. He uses his knowledge to educate patients, the community and cyberspace on the best way to avoid and / or manage chronic diseases using lifestyle and targeted supplementation.







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Category: Tissue Necrosis Factor (TNF)
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