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ZINC IMPACTS ON OUR BODY TO PREVENT OXIDATIVE DAMAGE – (10-15-03)

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Zinc Modulates PPARgamma Signaling and Activation of Endothelial Cells

Add zinc to the list of nutrients that has an impact on insulin resistance right next to chromium, vanadium and CLA. Considering that zinc is involved in a large number of enzymes that protect our bodies from oxidative damage, we know that a deficiency can have a wide range of negative effects.

nutrition.org — Abstracts: Meerarani et al. 133 (10): 3058

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CLA ABILITY TO ENHANCE INSULIN SENSITIVITY AND PREVENT CANCER – (10-15-03)

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Conjugated Linoleic Acid: Regulation of Adiposity and Insulin Sensitivity

CLA has gotten quite a bit of press over the past few years in regards to its ability to enhance insulin sensitivity and prevent certain types of cancer. Remember that in an ideal (read: non-commercially grown…) situation, cattle will eat grass and other greens. The fats from this diet then gets converted by beneficial bacteria in the gut to produce CLA which shows up in the meat as well as the milk of the animal. However, commercial cattle these days are fed corn and loaded with antibiotics…

nutrition.org — Abstracts: Brown and McIntosh 133 (10): 3041

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HOW TO MANAGE INSULIN RESISTANCE CLINICALLY – (12-22-03)

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Does Metformin Improve Clinical Features of Polycystic Ovary Syndrome?

This is a Cochrane Collaboration review of the medical literature and the bottom line is that metformin (a drug that increases insulin resistance) is an effective first line approach to anovulation in PCOS. I’m not entirely convinced that managing insulin resistance is being used clinically, however, and the birth control pill is still a common treatment (which, ironically, worsens insulin resistance…). As for these findings, I of course would advocate first using lifestyle changes and functional medicine approaches such as dietary changes, exercise and supplementation such as chromium or CLA.

Cochrane for Clinicains: Putting Evidence into Practice – December 1, 2003 – American Family Physician.

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