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Vitamin D supplementation

LOWER LEVELS OF IL-10 EQUALS LESS INFLAMMATION – (02-11-07)

April 8, 2012 by James Bogash

Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure

This study found that Vit D was able to lower the levels of a compound called IL-10.  While IL-10 is not the queen of all inflammatory mediators, it is very high up on the hierarchy.  This means that IL-10 turns on a bunch of other enzymes involved in inflammation.  So, lower levels of IL-10 equals less inflammation.

While this study was done on congestive heart failure patients, it has ramifications for every other type of autoimmune disease as well.  Also, the levels used, 50 micrograms (about 2,000 IU), is definitely a good dosage.

Read entire article here

Filed Under: Inflammation, Vitamin D Tagged With: autoimmune disease, congestive heart failure, cytokine, IL-10, inflammation, Vitamin D supplementation

BUT ISN’T THAT TOO MUCH VITAMIN D?

March 31, 2012 by James Bogash

We’re not going to rehash the benefits and frequency of deficiency of vitamin D here.  If you’re bored sometime, you can read all about vitamin D in past blog posts.  What we will review here is dosages and how mainstream medicine has been approaching the “vitamin D thing.”

First of all, lab values put normal levels of serum 25-OH vitamin D at 30-100 ng/dl.  It is widely excepted among experts in functional medicine that the optimal range is more like 60-100 ng/dl.

It seems like everyone is checking patients’ vitamin D levels these days, but the approach to deficiencies vary.  It is not uncommon for some of my patients to be told they have low vitamin D and put on 50,000 IU of the prescription form of vitamin D (ergocalciferol, or D2).  As high as these levels sound, they do not usually move blood values more than 10 or 20 ng/dl, most often leaving the patient still below optimal.

In our office, we generally start supplementation levels at 2,000 IU per day and move up from there depending on the clinical picture of the patient.  Our office uses an emulsified form of vitamin D3, which is very, very inexpensive, easy to take (can be taken once / week) and very high quality.  What more could one ask for??

However, when we recommend levels beyond 2,000 for specific patients, some are surprised at recommendations up to 6,000 or 10,000 IU / day, thinking this is a very high level (and yet don’t usually question the prescription, low quality 50,000 /  week, which is 7143 IU / day).

This particular article addresses the safety aspects of higher levels of vitamin D.  The author’s review concludes:

  1.  1500 IU is the lowest level needed to positively impact chronic disease risk
  2. Long-term daily intakes up to 10 000 IU of vitamin D do not show signs D toxicity

While it is not common that we recommend as high as 10,000 IU / day, it is considered safe with no signs of toxicity in the medical literature.

Filed Under: Vitamin D Tagged With: Vitamin D supplementation, vitamin D toxicity

CAN $10 / YEAR PROTECT YOUR CHILD FROM THE FLU?

January 30, 2012 by James Bogash

CAN $10 / YEAR PROTECT YOUR CHILD FROM THE FLU? The answer might be yes. A small trial of Vitamin D supplementation (1200 IU / day would run less than $6 for a year through our office) showed a 58% reduction in the risk of getting the flu in schoolchildren. This is not the first trial to show positive results.

Overall, the results in these studies have far outstripped the benefits of vaccination at a mere fraction of the costs. So will we see the CDC switching to spending millions of dollars educating the public about the benefits of rational sun exposure for our kids?

Read entire article here

Filed Under: Influenza, Vitamin D Tagged With: flu, Vitamin D supplementation

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