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tyrosine

Meals rich in carbs or proteins on plasma tryptophan and tyrosine ratios – (01-09-03)

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Meals rich in carbs or proteins on plasma tryptophan and tyrosine ratios

This is an important consideration. Tryptophan crosses the blood brain barrier to get converted to serotonin. Serotonin helps modulate sleep and mood and satiety (drugs like Prosac work to increase levels of serotonin by increasing the time it is able to affect nervous transmission). However, tryptophan has a harder time crossing the BBB with competition from other amino acids. So, paradoxically, foods with lots of protein will contain higher levels of trypthophan, but less of this actually makes it to the brain because of the competition from the other amino acids. Foods such as soybeans, bananas and beans have relatively high tryptophan levels can help to increase brain tryptophan. In addition, supplemental 5-HTP has been shown to increase brain serotonin levels as well.

AJCN — Abstracts: Wurtman et al. 77 (1): 128

Read entire article here

INFLAMMATION LEADS TO DEPRESSION IN ELDERLY

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Psychological problems seem to be everywhere in today’s society.  The knee jerk reaction is to medicate.  The problem with these drugs is that they really don’t hold up to well against placebo.  As a matter of fact, for the vast majority of patients, they are just plain ineffective.

Before we go into the gist of this article, we need to cover some basic neurochemistry.  There are certain amino acids that our body’s use to convert to neurotransmitters.  The most famous of which is probably tryptophan, which the body uses to convert to serotonin.  Tyrosine gets converted to epinephrine and norepinephrine (adrenaline) in the adrenals as well as dopamine in the dopaminergic cells of the brain.  Using this knowledge, you can actually use supplements containing tryrosine and / or 5-hydroxytryptophan (5-HTP) to help manage depression or anxiety.

This particular study takes an interesting look at what inflammation does to these amino acids in the elderly.  The enzyme indoleamine-2,3-dioxygenase (IDO) breaks down tryptophan, keeping it from being used to make serotonin.  Inflammation seem to speed up this enzyme, breaking down tryptophan before it can be used to produce serotonin and help the brain and our moods function better.

The enzyme guanosine-triphosphate-cyclohydrolase-1 (GTPCH1) is required to produce a compound called BH4, which the body then uses to produce, ultimately, tyrosine and the neurotransmitters noted above.

If all this seems a little too complex for dinner conversation, just remember that inflammation is a major player in much of what goes on in our bodies and brains.  Managing any concern or condition (in this particular case, psychological problems in the elderly) needs to incorporate methods to lower inflammation.

This means a plant based diet.  Lowering of omega-6 fatty acids and increased intakes of omega-3.  It means no processed foods.  Exercise.  Stress management.  The list is almost endless. 

The bottom line is that treatment of any psychological problem needs to encompass the entire body to be the most effective it can be.  Anything short of this is not good medicine.

http://www.sciencedirect.com/science/article/pii/S0006322310012783