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naringenin

ApoB is inhibited by the flavonoids, naringenin and hesperetin – (05-31-01)

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ApoB is inhibited by the flavonoids, naringenin and hesperetin

This japanese sounding title refers to the ability of certain natural compounds found in various fruits, to lower cholesterol levels. Ironically, naringenin is the substance in grapefruit that leads to the recommendation of avoiding it (actually…only about 50% of patients on coumidin get this recommendation…) while on coumidin because of its ability to inhibit phase I detoxification in the liver.

J. Lipid Res. — Abstracts: Wilcox et al. 42 (5): 725

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Inhibition of hepatocyte apoB secretion by naringenin – (09-19-02)

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Inhibition of hepatocyte apoB secretion by naringenin

Recall that naringenin is a bioflavanoid found in grapefruit and is well known to inhibit cytochrome P450 action–thus leading to potentially dangerous interactions with blood thinners. Here we see an apoB (protein carrier of lipids known to be associated with CVD risk) lowering effect of this same substance.

J. Lipid Res. — Abstracts: Borradaile et al. 43 (9): 1544

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