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monotherapy

Consumption of NSAIDs and the Development of Congestive Heart Failure in Elderly Patients – (04-17-00)

May 5, 2013 by James Bogash

This is one of the best ways to combine the best of nutrition w/ the best of Western medicine. But don’t hold your breath waiting for it to become standard prescription practice.

Investigational studies of a formulation of extended release niacin and lovastatin show that the combination is safe and well-tolerated and that it improves a number of lipid profile markers. Dr. Moti L. Kashyap of Long Beach Veterans Administration Medical Center, in California, presented findings from a study of combination therapy in 814 patients in a dose-escalating open-label study during the 49th scientific sessions of the American College of Cardiology. Dosages ranged from niacin 500 mg + lovastatin 10 mg to niacin 2,000 mg + lovastatin 40 mg. Dr. Kashyap said that the combination drug, Nicostatin (Kos Pharmaceuticals, Miami Lakes, Florida), has additive effects over monotherapy with either of the two drugs alone, especially in lowering LDL cholesterol, raising HDL cholesterol and lowering triglycerides.

Whoa!! Very important news. We all know that NSAIDs (ibuprofin and it’s kin…) have damaging side effects on the stomach, liver, joints and kidneys. But increasing your risk of congestive heart failure? If a natural remedy had even 1/10th of the dangers of NSAIDs, it would be yanked off the market faster than you could say “Celebrex”. Remember the tryptophan contamination way back when? A handful of deaths were attributed to a contaminant in the supplement (not the supplement itself) and it was yanked off the shelves and still can’t be sold; yet, an estimated 15,000 people die from NSAIDs per year!!!

Consumption of NSAIDs and the Development of Congestive Heart Failure in Elderly Patients: An Underrecognized Public Health

More benefits of monounsaturated fats…

Olive Oil and Reduced Need for Antihypertensive Medications

Filed Under: Heart Disease, NSAIDs Dangerous Tagged With: HDL cholesterol, LDL cholesterol, lovastatin, monotherapy

Role of Coenzyme Q10 in Chronic Heart Failure, Angina, and HTN – (08-13-01)

May 5, 2013 by James Bogash

Role of Coenzyme Q10 in Chronic Heart Failure, Angina, and HTN

It’s nice to see CoQ10 getting some recognition in the pharmacology journals, however, in the conclusion to this article, the author suggests that, while CoQ10 does show some promising results, it is not recommended for use at this time as monotherapy. Huh?? No self respecting physician who understands natural medicine would ever recommend just one thing for cardiovascular disease. It’s a program, not an isolated therapeutic agent. I feel it may be a long while yet before we see natural therapeutics used in trials as they are used in clinical practice.

Pharmacotherapy 21(7):797-806, 2001 Coenzyme Q10 (CoQ10) has a pathophysiologic role in many disease states. The purpose of this review is to provide recommendations regarding the safety, efficacy, and dosing of CoQ10 in the management of chronic heart failure (CHF), angina, and hypertension. Coenzyme Q10 administered orally has favorable actions in the described cardiovascular conditions and appears to be safe and well tolerated in the adult population. Issues concerning optimum target dosages, potential interactions, monitoring parameters, and the role of CoQ10 as a monotherapeutic agent need to be investigated further. Favorable effects of CoQ10 on ejection fraction, exercise tolerance, cardiac output, and stroke volume are demonstrated in the literature; thus, the use of CoQ10 as adjuvant therapy in patients with CHF may be supported. Conclusions: Coenzyme Q10 therapy in angina and hypertension cannot be substantiated until additional clinical trials demonstrate consistent beneficial effects. However, CoQ10 may be recommended as adjuvant therapy in selected patients with CHF. At this time, CoQ10 should not be recommended as monotherapy or first-line therapy in any disease state.

Filed Under: Heart Disease Tagged With: angina, chronic heart failure, coenzyme Q10, HTN, monotherapy

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