RESISTANCE TO INJURY FROM CALORIE INTAKE – (05-29-03)

Intermittent fasting effects on glucose metabolism, neuronal resistance to injury from calorie intake. One of the only well founded true “anti-aging” approaches out there is calorie restriction w/o nutrient restriction.Well, unfortunately, this approach is just not fun. Well, we may have an easier alternative. Alternate day fasting in mice appears to produce the same favorable […]

CALORIE RESTRICTION PROMOTES MITOCHONDRIAL BIOGENESIS – (11-21-05)

Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS Despite reading the ads and articles you see everywhere, the ONLY approach that has been shown to improve lifespan in mammals is calorie restriction without nutrient restriction. Period. However, the pharmaceutical companies are looking for what physiological pathways are triggered with caloric restriction so […]

ETIOLOGY OF INSULIN RESISTANCE – (05-29-06)

Etiology of Insulin Resistance While insulin resistance is probably one of my more often used soapboxes, my heart truly lies with mitochondrial dysfunction as undoubtedly this trigger that begins all chronic diseases of today’s time. That is why the approach to managing many chronic diseases is so similar–they all focus around reducing damage to the […]

SKIPPING MEALS RESULT IN LOSS OF LEAN BODY MASS – (12-04-06)

Altered Skeletal Muscle Subsarcolemmal Mitochondrial Compartment During Catch-Up Fat After Caloric Restriction While there will be no jaws dropping if I mention that the rates of obesity are skyrocketing and that most weight loss programs out there do not work and frequently result in rebound weight gain greater than what was lost in the first […]