Zinc inhibition of gamma-aminobutyric acid transporter 4 (GAT4) reveals a link between excitatory and inhibitory neurotransmission

Sorry for the long title, but this one has some interesting implications.  First, a bit on neurotransmitters.  Glutamate is excitatory and stimulates the neuron to fire.  Too much and you can ultimately burn out the neuron (this is one of the concerns with neuroexcitotoxins like MSG and aspartame).

GABA is inhibitory and counteracts the effects of glutamate.  Many anti-seizure medications act by mimicking GABA.  With this background, one of the long-time findings is that aluminum can increase risk of Alzheimer’s.  Well, we know that aluminum knocks out zinc in the body, much like those perpetual motion ball thingies.

In this article, we see that synapses that release glutamate, which, in too high levels can damage a neuron, also release zinc at the same time to protect against overactive glutamate.  It’s funny how we develop a theory or assumption, and years or even decades later we begin to elucidate exactly why the theory works.

Read entire article here

James Bogash

For more than a decade, Dr. Bogash has stayed current with the medical literature as it relates to physiology, disease prevention and disease management. He uses his knowledge to educate patients, the community and cyberspace on the best way to avoid and / or manage chronic diseases using lifestyle and targeted supplementation.