Dehydroepiandrosterone-Sulfate Inhibits Nuclear Factor-kappaB-Dependent Transcription in Hepatocytes, Possibly through Antioxidant Effect
Sorry for the long title, but this one is interesting. NFkappaB is a transcription factor that promotes inflammation. By blocking NF kappa B’s action, the overall burden of inflammation can be lowered. In this study, it was shown that DHEA-s lowers the effect of KF kappa B, essentially producing an anti-inflammatory response. Why is this important? DHEA is produced by the adrenal cortex, but the production of this compound is affected by stress. More stress will produce cortisol instead of DHEA (called the “pregnonalone steal”). Follow the pattern out from there. JCEM — Abstracts: Iwasaki et al. 89 (7): 3449