Baclofen on 24 hour pH metry and symptoms in GERD.
Okay, so it is interesting that a muscle relaxer such as baclofen has a beneficial effect on reflux disease. However, what I find particularly disconcerting is that this class of drugs raised the pH of the stomach (essentially lowered acid production). Given that many patients (with and many without GI complaints) do not make enough stomach acid, the fact that a drug unrelated (at least until this study..) to acid production would interfere with this essential physiologic action opens up a wide Pandora’s box of downstream mayhem.
Gut — Abstracts: Ciccaglione and Marzio 52 (4): 464