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inflammatory disease

Serum levels of YKL-40 and CRP in patients with hip osteoarthritis – (10-26-00)

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Serum levels of YKL-40 and CRP in patients with hip osteoarthritis

This article is a little technical. For most of medical history, despite the use of the ending “itis,” osteoarthritis has not been considered an inflammatory disease. However, recent research has shown that inflammation is indeed a factor. This can change the entire was we view the treatment of OA. And opens up new therapies for dealing with and preventing OA. Many researchers are begining to show that the underlying cause of OA is a nutritional problem of the bone underneath the joint.

Ann Rheum Dis — Abstracts: Conrozier et al. 59 (10): 828

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Is Type-2 Diabetes an Inflammatory Disease? – (08-25-00)

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Is Type-2 Diabetes an Inflammatory Disease?

This is not a new theory. Inflammation in the human body can be a devastating process and is believed to contribute to most diseases known to man. This is a nice summary of the link between inflammation and Type 2 diabetes.

The 82nd Annual Meeting of the Endocrine Society Dr. Steven Shoelson of the Joslin Diabetes Center, Boston, Massachusetts, presented the first lecture entitled, “The I-kappa B Kinase Mediates Insulin Resistance in Diabetes and Obesity.”[1] The provocative question at the outset was — is type-2 diabetes an inflammatory disease? Certainly, patients with type-2 diabetes exhibit circulating markers of an “acute phase response,” and some of these, such as tumor necrosis factor-alpha, may contribute to the pathophysiology of type-2 diabetes. However, is there a rationale for treating type-2 diabetic patients with anti-inflammatory drugs? Dr. Shoelson gave historical evidence — dating from 1876, but “rediscovered” as recently as 40 years ago — that high doses of aspirin (ASA) of the order of 10 g per day can attenuate hyperglycemia quite markedly. The Joslin investigators hypothesized that I-kappa B kinases (IKKs), key regulators of the NF-kappa B pathway of proinflammatory signaling, might be the target of ASA, since this dose is known to inhibit their activity. (Of note, much smaller doses are needed to inhibit the cyclooxygenase enzymes that are generally the target of ASA’s anti-inflammatory actions, but these doses of ASA do not appear to affect glycemia.)

Hyperketonemia Increases Tumor Necrosis Factor-alpha Secretion – (07-01-02)

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Hyperketonemia Increases Tumor Necrosis Factor-alpha Secretion

If you are a regular reader of Updates, I’m sure you’re aware of just how much I support the high protein diets that are designed to throw the human body into that dangerous state called ketosis. Here is further support against the “health improving” high protein diets…ketosis leads to upregulation of TNF-alpha, a cytokine intimately related in turning up the level of inflammation in the body. Consider that the latest and greatest drugs for rheumatoid arthritis and Crohn’s disease are TNF blockers because increased TNF-alpha is believed to be a contributing factor to the perpetuation of these chronic inflammatory diseases.

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