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cranberry

Cranberry; And You Thought it was Just Good for UTIs

June 13, 2015 by James Bogash

cranberries and the microbiome
Photo courtesy of http://www.freeimages.com/profile/Keira

It’s pretty much common knowledge that cranberry is good for urinary tract infections.  But, just like many other food items, the benefits extend far beyond this.

Let’s face it, though, the berries, as a group, have powerful benefits.  Blueberries, strawberries, lingonberries, cranberries.  Berries pack a pretty powerful phytonutrient (plant-based protective compound) punch.

And this benefit is across chronic conditions.  From cancer to diabetes to heart disease.  The studies are quite numerous and consistent.  And let’s face it—berries are not too painful to add into a healthy lifestyle.

Sometimes, though, with natural approaches, the way the approach is working may be far outside the realm of what we think it is doing.  As an example, when it comes to cranberries, I generally think about the antioxidant / protective compounds the are found in the berries and how they can protect against damage at the cellular level.

In addition, the sugar alcohol (d-mannose) found in cranberries is absorbed into your body but not used.  As a result, the d-mannose shows up in the urine where it helps to wash out bacteria present in the urinary tract to provide the well-known benefit for urinary tract infections.

But what if there is something more going on?  Something that may have to do with, say….the gut?

Regular readers of the blog know how much I revere any knowledge that can help me understand more about how the microbiome (gut bacterial population) affects health and how I can help patients positively affect their gut.

Which brings us to this particular study.  In it, researchers evaluated the effect of a cranberry extract on the gut bacterial flora in a group of mice who were fed a high-fat, high-sugar, pro-diabetic diet.  Here’s what they found:

  • The cranberry extract slowed down the expected weight gain and abdominal obesity.
  • Cranberry treatment, led to less triglyceride accumulation.
  • The extract protected against liver oxidative stress and inflammation (the liver weight was less).
  • Insulin action was improved (improved insulin tolerance, lower HOMA of insulin resistance and decreased glucose-induced hyperinsulinaemia during an oral glucose tolerance test).
  • There was less intestinal inflammation and oxidative stress.
  • But, despite all of this, the most interesting finding was that there was a marked increase in the bacterium Akkermansia.

Akkermansia?

Isn’t that just south of Istanbul?

Akkermansia muciniphila is a relatively newly-discovered bacteria present in the gut that has a unique ability to break down mucin.  Mucin is a mucous-like compound that lines the entire gastrointestinal tract.  Mucin can provide protection to the cells lining the gut, but it can also protect nasty bacteria in your gut that hide behind a layer of mucin from protection.

More importantly, as we see in this study, A. muciniphila seems to have a pretty potent anti-diabetic effect on the organism that it thrives in.  So, based on this study, it would seem that cranberry, as both the fruit and the extract, may give you the ability to fight off weight gain and diabetes.  Pretty cool.

One quick note:  If you choose to use real cranberries, absolutely avoid the sugared-up, sunflower coated variety.  See if you can find straight-up cranberries.  If this isn’t your speed, you can always check out what your local chiropractic-nutritionist or Amazon has to offer.

Filed Under: Probiotic Tagged With: Akkermansia, cranberry, microbiome, probiotic

CRANBERRY VS ANTIBIOTICS FOR UTI

August 16, 2011 by James Bogash

Cranberries are one of those natural remedies that come to mind first thing when someone mentions urinary tract infections.  Usually, when a recommendation like cranberries for UTIs has passed the test of time, it’s because there is validity to the claim.

So, we can accept that cranberries are good for UTIs, but are they being used in the most effective manner?  This particular study put cranberry capsules head to head with an antibiotic regimen for a year in women who suffered with recurrent UTIs.

The results were that the antibiotics were more effective, but within a single month antibiotic resistance was beginning to develop.  Keep in mind that the cranberry was effective, just not quite as effective as the antibiotics by a few percentage points.

Now for the important things to consider.  First, I am not a fan of using supplements vs the actual juice.  Then, it needs to be the real stuff, not the cocktail, sugar laden junk that many buy thinking it’s going to help with their UTIs.  I will usually tell patients to down a jar in a day for the strongest effects.

Even better is a two step approach.  First, it is actually a non-metabolized sugar called d-mannose that is believed to do the work of the cranberries.  So our bodies absorb it, but most of the d-mannose shows up in the urine and has no effect on blood sugar. 

E. coli is the most common agent causing UTIs and creates problems when the pili attach to the lining of our urinary tract.   When d-mannose is present, however, the E. coli attach to the d-mannose instead of your urinary tract and subsequently gets washed away.  So using the d-mannose directly instead of the cranberry juice can be far more effective in managing chronic UTIs. 

The other step involves making sure that E. coli does not make it to the opening of the urinary tract (the urethra) in the first place.  In a normal female who has never been on antibiotics will have plenty of healthy bacterial flora present to constantly secrete low levels of lactic acid, thus keeping the E. coli from the urethra in the first place. 

Ironically, antibiotics may actually increase the risk for UTIs by destroying this normal flora, making it easier for E. coli to make it to the urethra.  So, the second step is actually using probiotic douches (preferably with distilled water, if not, then vinegar is ok) daily for a week.

The combination of the d-mannose and probiotic douches will be far more effective than the cranberry juice alone.  So, if this study finds that antibiotics are only a little better than cranberry juice, I’d love to see this 2 step approach go head to head with antibiotics.

Read more…

Filed Under: Probiotic, Urinary Tract Infections Tagged With: antibiotics, cranberry, d-mannose, probiotics, urinary tract infections, UTI

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