S-Adenosyl-L-Methionine Increases Skeletal Muscle Mitochondrial DNA Density and Whole Body Insulin Sensitivity Wow!! While I somewhat remember that the methylation pathway and SAMe feed into glutathione (an essential component of one of the body’s most potent detoxifying ezymes and antioxidant enzymes), I can honestly say using methylators like SAMe, B12 or betaine had not come […]
CoQ10 Deficiency and Response to Supplementation in Pediatric and Adolescent Migraine Given that we have shifted our thinking of the cause of migraines to a mitochondrial dysfunction / oxidative stress model, the results of this study should come as no surprise. I still find it very bothersome, though, that we have so many patients being […]
Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging. Calorie restriction has a definite, positive effect on the functioning of mitochondria. This study adds to our understanding, and finds that CR also helps to increase the efficiency of the enzymes in the cell well of neurons that […]
Molecular Mechanisms of Insulin Resistance in Humans and Their Potential Links With Mitochondrial Dysfunction As much as I consider insulin resistance to be a devastingly unrecognized problem in today’s society, the truth is that mitochondrial dysfunction is the underlying cause of IR. This study is just one more in the growing collection supporting the concept […]
Mitochondrial dysfunction as a cause of ageing Ah. My favorite topic. The Holy Grail of chronic disease prevention. The lynchpin of cellular health. Anything to harms mitochondria numbers or function is bad for us and leads to chronic disease. Anything that helps increase the number and efficiency of mitochondria promotes health and avoids chronic disease. […]
