Molecular Mechanisms of Insulin Resistance in Humans and Their Potential Links With Mitochondrial Dysfunction

As much as I consider insulin resistance to be a devastingly unrecognized problem in today’s society, the truth is that mitochondrial dysfunction is the underlying cause of IR.

This study is just one more in the growing collection supporting the concept that defects in a muscle cell’s ability to generate energy and protect against energy generation predispose IR. It is likely that too much glucose in the cell causes the cell to back off on energy production in an attempt to protect itself, starting the cycle. Luckily, lifestyle changes targeted for helping w/ IR are the very same that help mitochondria function better. Funny how that works out.

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James Bogash

For more than a decade, Dr. Bogash has stayed current with the medical literature as it relates to physiology, disease prevention and disease management. He uses his knowledge to educate patients, the community and cyberspace on the best way to avoid and / or manage chronic diseases using lifestyle and targeted supplementation.