Anti-TNF, IL-10, antibiotics in indometacin-induced bowel inflammation
This is an interesting article that implicates both TNF-alpha and anaerobic bacteria in the development of Crohn’s disease. So we are using fancy new drugs to block TNF-alpha (we all know my opinion on THIS one…); where is the other half of the therapy designed to address to harmful bacteria? A global approach to Crohn’s includes probiotics, avoidance of refined sugars and managing insulin levels and obesity (both stimulate TNF-alpha production).
Synergy : Alimentary Pharmacology & Therapeutics 15 (11), 1827-1836