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topiramate

Migraines in Children: How Well Do Meds Work?

April 18, 2013 by James Bogash

Few things are as difficult as seeing your child in pain. I remember when Keegan broke his leg and how much it hurt me knowing he hurt.

Headaches in children can be just as unbearable for a parent, but with the added concern of whether something more ominous is causing the headaches. While misguided, most parents will present to his or her pediatrician for evaluation and some type of answer. This usually prompts imaging of the brain despite the absence of red flags.  MRI if you are lucky, CT scans if your pediatrician wouldn’t recommend a medical journal if he or she got whacked upside the head with it.

Side note: In the absence of red flags, advanced imaging is not recommended.  Even when imaging should be done, it should be an MRI (with the single exception of looking for a subarachnoid hemorrhage, which is much more likely to occur in the elderly population). The radiation exposure with a CT scan is extremely high and has been linked to some 29,000 cancers per year.

So everything comes back normal, but your little baby is still having nightmare headaches. It’s nice to know there is nothing “real” going on, but this doesn’t take care of the migraine headaches. Your pediatrician’s only answer at this point is medication.

It is unfortunate, but a referral to a chiropractor is rarely undertaken before the medication. Many of the kids who come into our office for treatment of his or her headaches have already tried everything including medications. Most often we are able to help in a very short period of time, although there have been cases over the years that treatment in our office was not able to help and we just became one more therapy in a long list of failed attempts.

Anecdotally, I can tell you that we do extremely well with headaches. However, our comprehensive approach (manipulation, soft tissue work, diet, stress management) to migraines in children has not been studied in any type of clinical trial that I’m aware of, so maybe I could understand a pediatrician’s reluctance to refer out to a chiropractor. After all, we don’t want to subject our children to anything that has no research to back it up, right?

Which, of course, brings us to this particular study.  Basically, researchers looked across multiple studies to see which medications have been shown to be effective for the treatment of migraines in children. Here’s what they found:

  • Topiramate (Topamax) led to 0.7 less headache days per month.
  • Trazodone was slightly less effective at 0.6 less headache days per month.
  • Drugs with no benefit included clonidine, flunarizine, pizotifen, propranolol, and valproate (Depakote).
  • A single trial of fluoxetine for chronic daily headaches found it ineffective.
  • However, kids given placebo experienced an almost 50% drop in headache days (down 2.7 days / month).

Basically, the evidence sucks for the use of most medications for treatment of migraines in children.

Placebo, on the other hand, plays a far, far stronger role in slashing headache frequency in the children in these studies. Something to consider strongly should your pediatrician recommend medications (with a long list of side effects) to help control migraines in children.

It also brings us back to the use of a comprehensive chiropractic approach to the treatment of headaches in children. Our care is extremely safe when compared to any medication, and, at least according to this review, it certainly couldn’t be any less effective!

Filed Under: Uncategorized Tagged With: headaches in children, migraine, migraine headaches, Migraines In Children, placebo, Prevention Of Migraines, topiramate

RISK OF SUDDEN DEATH IN EPILEPSY – (03-06-05)

May 10, 2012 by James Bogash

Effects of the antiepileptic drugs lamotrigine, topiramate and gabapentin on hERG potassium currents

I have a patient that has seizures and of the providers and specialists and relatives’ friend who are doctors all have just one answer–anti seizure medications.  While these drugs do not effect the underlying process that is causing the seizures (all research is pointing towards a mitochondrial/oxidative stress model of many neurological disorders) they do have a long list of side effects–and on average–a 30% efficacy.

One of the concerns of many epileptics is the risk of sudden unexplained death in epilepsy (SUDEP).  Wouldn’t that be a kick in the pants if the medications for epilepsy are actually a major causative factor in SUDEP?

Read entire article here

Filed Under: Seizures / Epilepsy Tagged With: antiepileptic drugs, gabapentin, lamotrigine, mitochondrial/oxidative stress model, seizures / epilepsy, SUDE, topiramate

TREATMENT OF CHRONIC MIGRAINE – (10-29-07)

April 15, 2012 by James Bogash

Efficacy and Safety of Topiramate for the Treatment of Chronic Migraine

Talk about a difference in perception!!! The authors conclude that “Topiramate is safe and generally well tolerated in this group of subjects with chronic migraine, a burdensome condition with important unmet treatment needs. Safety and tolerability of topiramate were consistent with experience in previous clinical trials involving the drug.”

Look at the data and tell me is “generally” means 10% of the study population stopped due to side effects. And all of this for a whopping 1.5/91 days decrease in headache over placebo. So, we’re going to spend, what, say $600 for 3 months Topamax to have 1.5 days less HA? But let’s cut chiro Rx to save money.

Read entire article here

Filed Under: Migraine Tagged With: Chronic Migraine, headache, placebo, topiramate

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