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Oral tolerance

Zinc Deficiency Suppresses Development of Oral Tolerance in Rats – (01-09-03)

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Zinc Deficiency Suppresses Development of Oral Tolerance in Rats

Oral tolerance is the process by which the immune system surrounding the GI tract (close to 2/3 of the immune system is centered around the GI tract) samples an antigen (such as a protein from foods) and decides that this substance is okay and sends that same signal out to the rest of the body. Without this process, our body would be under the impression that we are under perpetual attack from proteins in our food.

nutrition.org — Abstracts: Finamore et al. 133 (1): 191

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Peyer’s patches are required for oral tolerance to proteins – (04-12-01)

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Peyer’s patches are required for oral tolerance to proteins

Oral tolerance is a method of treating certain diseases, most commonly allergies, by which a small amount of a substance that the patient is sensitive to is taken orally. This substance than is exposed to the immune system centered around the GI tract, and the immune system downregulates the response to this substance (tells the rest of the body that this substance is okay). This approach has also been used with rheumatoid arthritis patients with very good results.

PNAS — Abstracts: Fujihashi et al. 98 (6): 3310

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