Since April 26, CDC has received 145 reports of pediatric deaths associated with influenza infection. Of these, 129 (89%) cases were associated with laboratory-confirmed 2009 pandemic influenza A (H1N1) virus. The remaining 16 pediatric deaths were associated with seasonal influenza or an influenza A virus for which the subtype was undetermined. In comparison, during the preceding five influenza seasons, the total number of reported pediatric influenza deaths ranged from 46 to 153, with an average of 82 deaths each year.