High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity: relevance to genetic disease and polymorphisms
Had to leave in the long title for those of you that stayed awake through biochemistry. The impact of this article on RDA is just short of staggering. We have talked about increased need for folic acid in the approximately 25% of the population with MHTFR genetic polymorphisms far beyond that of the RDA. This concept begins to look at the concepts of SNPs, or single nucleotide polymorphisms. SNPs begins to view every patient as an individual with separate genetic variations with different biochemical needs. There are currently lab tests just being offered that can identify hundreds of these SNPs with a single urine test. Imagine the impact on human health–a urine test that identifies genetic “weaknesses” that can be overcome with certain lifestyle interventions. The ramifications are beyond almost anything we have seen before in medicine and health.
AJCN — Abstracts: Ames et al. 75 (4): 616