Combination of Riboflavin, Magnesium, and Feverfew for Migraine Prophylaxis
Talk about an unexpected result! This trial used 25 mg riboflavin as a placebo, and, when all the data was in, both placebo and active arm experienced similar, positive effect. Remember that riboflavin is a part of flavin adenine dinucleotide (FAD) which participates in the formation of ATP through the electron transport chain. Recall from previous Updates that I feel we are moving towards an oxidative stress etiology for migraines. The benefit of riboflavin on migraine once again goes into the evidence pool suggesting that poor mitochondrial function leading to oxidative stress is a main contributing factor to onset of migraines.
A Combination of Riboflavin, Magnesium, and Feverfew for Migraine Prophylaxis: A Randomized Trial – Headache, Vol 10, Issue 1, Pages 33-34 –