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calprotectin

Can calprotectin simplify the diagnosis of irritable bowel syndrome? – (08-05-02)

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Can calprotectin simplify the diagnosis of irritable bowel syndrome?

Calprotectin is a marker for inflammation of the GI tract and is suggested in this study as a fecal marker to differentiate IBS from inflammatory bowel disease. While this is an easy and effective way to differentiate, I have a problem with this article referring to IBS as a non-organic disease. I would much rather have researchers refer to IBS as a functional disorder. By labeling it as a non-organic disease I envision a condition that is psychogenic in origin, which I do not feel that IBS is. It may be flared by stressful situations, but that hardly constitutes a psychogenic illness.

Entrez-PubMed

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TWO STRONGEST MARKERS TO PREDICT RELAPSE – (03-06-05)

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Calprotectin is a stronger predictive marker of relapse in ulcerative colitis than in Crohn’s disease

It is strange that two of strongest markers to predict relapse are tests most GI docs have probably never heard of.  Altered GI permeability (“leaky gut”) as evidenced by a lactulose/mannitol challenge is another strong predictor of relapse.

The nice thing is that these markers can be easily checked and modified with natural approaches such as omega-3 fatty acids, non-processed diets and probiotic supplementation.

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