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Arthritis Pain

Cyclo-Oxygenase 2 Function Is Essential for Bone Fracture Healing – (10-03-02)

April 28, 2013 by James Bogash

Cyclo-Oxygenase 2 Function Is Essential for Bone Fracture Healing

This is a clinical decision nightmare. The newest arsenal in the fight against arthritis pain is the highly overused class of drugs called COX-2 selective inhibitors (Celebrex, Vioxx). These are supposed to be safer on the GI tract. Recent concerns have arisen over potential damage to the heart with their use, and now we see that the COX-2 enzyme is needed for proper bone healing. How many patients out there are improperly given the selective COX-2 inhibitors for pain relief following joint replacement surgery or fracture? Have to admit that those pharmaceutical reps are doing a good job pushing off-label uses for their drugs!

Read entire article here

Filed Under: Arthritis, Osteoporosis Cures and Bone Health Tagged With: Arthritis Pain, Bone Fracture Healing, Celebrex, COX-2 inhibitors, Vioxx

Arthritis Relief: Is Ginger Good for Joint Relief?

October 8, 2012 by James Bogash

We want to live life to our fullest; this means no arthritis pain. Many use drugs for arthritis relief, but safety is a concerns. Is ginger good for joint relief?

Mother Nature knew what she was doing.  Us–not so much.

It seems like anytime we try to mess with nature we screw things up.  Anti-inflammatories are certainly on this list.  Here is how things usually work:

  • Nature makes a compound that positively effects some pathway in our body.  This effect is usually subtle and takes time for the effect to show, but has a very good safety profile for long term use.
  • Scientists find said natural compound and modify it so that it has a strong short term effect but thus becomes dangerous in the long run.

Overall, the drug companies try to find compounds that have the greatest effect at the lowest concentrations.  They want compounds with as high of a LD50 as possible (the LD50 is the level at which the compound kills 50% of the study participants).  But they all will kill at high enough dosages (even water can kill if you stuff enough of it in our bloodstream).

While the list of problems associated with anti-inflammatories (specifically the NSAID class of drugs) is quite long and has been addressed in prior posts that can be read here, suffice it to say that I consider this one of the most dangerous classes of drugs, resulting from a combination of the broad spectrum of subtle side effects combined with the near-universal belief in their safety by the general population.

 There are many natural, unadulterated compounds that have been shown to lower inflammation and have solid research behind them.  Curcumin / turmeric, boswellia, cat’s claw and proteolytic enzymes to name a few.  Ginger is also on the list.

This particular study looks at the effectiveness of ginger to both control pain associated with arthritis as well as protect the lining of the stomach (a MAJOR concern with NSAIDs).  It was compared with diclofenac (Voltaren), a common anti-inflammatory used for arthritis pain.

The safety profile of ginger was, as expected, much better on the stomach than the diclofenac.  Surprisingly, the pain relief was equivalent in both groups (as measured by the Visual Analog Scale, or VAS).

If you have tried ginger for arthritis relief, what was your experience?

Filed Under: Arthritis, NSAIDs Dangerous, Osteoarthritis Tagged With: Arthritis Pain, arthritis relief, diclofenac, ginger, natural pain relief

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