Cardiovascular Effects of NO Synthase Inhibition with Asymmetrical Dimethylarginine

Biochemistry 501. ADMA is a compound that can be considered to alter ego of nitric oxide. Nitric oxide is a vasodilator and opens up blood vessels and lowers BP. When ADMA levels go up, the enzyme that produces nitric oxide is inhibited, thus resulting in negative effects on blood pressure and blood vessels. So what causes ADMA levels to go up? Back to our ole’ friend hyperinsulinemia. Elevated insulin inhibits the enzyme that breaks ADMA levels. I know I sound like a broken record, but I feel Syndrome X is probably the #1 condition that negatively impacts health in the developed nations, albeit indirectly. Yet it remains the big,huge, gargantuan, super-sized neon purple and construction orange elephant in the clinician’s room. Circulation — Abstracts: Kielstein et al. 109 (2): 172 –

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James Bogash

For more than a decade, Dr. Bogash has stayed current with the medical literature as it relates to physiology, disease prevention and disease management. He uses his knowledge to educate patients, the community and cyberspace on the best way to avoid and / or manage chronic diseases using lifestyle and targeted supplementation.