Mice That Overexpress Human UCP-3 Eat More Yet Weigh Less – (08-28-00)

Mice That Overexpress Human UCP-3 Eat More Yet Weigh Less

Uncoupling protein (UCP) is a protein found in humans that essentially burn fat at high rates. In babies and mammals we call tissues with high levels of UCP brown fat. The levels of UCP in a particular patient will undoubtedly be found to be a factor in a patient’s overall weight.

Nature 2000;406:415-418 Transgenic mice that overexpress the human uncoupling protein-3 (UCP-3), a close relative to the brown adipose tissue-expressed UCP-1, consume more calories but weigh less than their wild-type littermates. In conclusion, while the findings do not prove that “UCP-3 is involved in the aetiology of obesity,” the results do indicate that alteration of UCP-3 expression may offer a new approach to obesity treatment.

James Bogash

For more than a decade, Dr. Bogash has stayed current with the medical literature as it relates to physiology, disease prevention and disease management. He uses his knowledge to educate patients, the community and cyberspace on the best way to avoid and / or manage chronic diseases using lifestyle and targeted supplementation.