gamma-Glutamyltransferase as a Risk Factor for Cardiovascular Disease Mortality

GGT is normally thought of as a marker of liver or gall bladder dysfunction (it is called a liver “function” test, but is actually looked for dead cells spilling more of the enzymes into the bloodstream–hardly a marker of “function” if you ask me…), but has been gaining increased popularity as a marker of CVD and insulin resistance. So, chalk yet another marker up for risk of insulin resistance and CVD. One thing I have not seen mentioned, however, is whether the relationship is direct or indirect.

Insulin resistance is known to cause an elevation of liver enzymes and non-alcoholic steatohepatitis (or called non-alcoholic fatty liver disease- NAFLD). So, is this just another marker of the damage that insulin resistance is doing, or does the GGT have a direct relationship to CVD? And does it matter??

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James Bogash

For more than a decade, Dr. Bogash has stayed current with the medical literature as it relates to physiology, disease prevention and disease management. He uses his knowledge to educate patients, the community and cyberspace on the best way to avoid and / or manage chronic diseases using lifestyle and targeted supplementation.