Effective and Safe Modification of Multiple Atherosclerotic Risk Factors – (02-12-01)



Effective and Safe Modification of Multiple Atherosclerotic Risk Factors

This article looks at the lowering of multiple risk factor for atherosclerosis simultaneously. As far as I’m concerned, this is the ONLY way to address this problem. Of interesting note in this study was the use of niacin, 500mg twice daily (a very reasonable dose) to raise HDL levels 30%. Add some exercise and avoidance of saturated fat and your LDL/HDL ratios will be looking pretty good!!

Am Heart J 140(5):792-803, 2000 Patients with peripheral arterial disease (PAD) are at an increased risk of cardiovascular mortality and morbidity and thus are an excellent group in whom to evaluate the feasibility and the effect of an aggressive multifactorial intervention on atherosclerotic vascular disease risk factors. The Arterial Disease Multiple Intervention Trial (ADMIT) was designed to determine the efficacy, safety, and compliance of an multifactorial therapy on selected atherosclerotic disease risk factors in patients with PAD. Niacin increased HDL cholesterol levels by 30%, with the majority of effect achieved at a dosage of 500 mg twice daily. Warfarin had an anticoagulant effect. The antioxidant vitamins resulted in a significant increase in vitamin E, C, and beta-carotene plasma levels. Overall, compliance was high and few adverse effects were reported. ADMIT demonstrates that it is both feasible and safe to modify multiple atherosclerotic disease risk factors effectively with intensive combination therapy in patients with PAD.

James Bogash

For more than a decade, Dr. Bogash has stayed current with the medical literature as it relates to physiology, disease prevention and disease management. He uses his knowledge to educate patients, the community and cyberspace on the best way to avoid and / or manage chronic diseases using lifestyle and targeted supplementation.







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Category: Cholesterol
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