TNF-alpha suppresses the expression of clock genes by interfering with E-box mediated transciption

In case you’re confused by this title, don’t worry–so am I. But the take home message from this mouse study is that TNF-alpha, a cytokine that produces inflammation in the body, interferes with the body’s sleep wake cycle, produces fatigue.

Fatigue is a very common complaint for patients presenting to their PCP. Unfortunately, the evaluation of fatigue in the typical doctors’ office does not extend beyond looking for anemia and checking the thyroid. Yet, these two problems don’t scrape the surface of what creates fatigue. Adrenal issues need to be looked at, and, as we see in this study, inflammation is a major player as well.

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James Bogash

For more than a decade, Dr. Bogash has stayed current with the medical literature as it relates to physiology, disease prevention and disease management. He uses his knowledge to educate patients, the community and cyberspace on the best way to avoid and / or manage chronic diseases using lifestyle and targeted supplementation.