Pharmacokinetics of a single large dose of cholecalciferol

Patients are frequently concerned with what they consider “high” dosages of Vitamin D. They look at their bone formulas, multivitamins and Vitamin D and think that they are going to overdose. While overdose is possible, the window of safety is very large with Vitamin D and usually requires dosages over 10,000 IU / day for several months before an issue may arise.

In this particular study they used a dosage of 100,000 IU at one time and found no notable side effects, with the authors recommending this level of dosage to be given every 2 months. Kind of makes you less worried about that whopping 400 IU in your calcium supplement your doctor recommended, huh?

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James Bogash

For more than a decade, Dr. Bogash has stayed current with the medical literature as it relates to physiology, disease prevention and disease management. He uses his knowledge to educate patients, the community and cyberspace on the best way to avoid and / or manage chronic diseases using lifestyle and targeted supplementation.