LifeCare Chiropractic

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Endometriosis

Nuclear PPARs and Have Opposing Effects on Monocyte Chemotaxis in Endometriosis – (07-12-01)

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Nuclear PPARs and Have Opposing Effects on Monocyte Chemotaxis in Endometriosis

Sorry for the long scary title, but PPARs are truly one of the hot buttons in disease research today. I really do believe that many of today’s chronic disease really stem from a relatively few biochemical defects that branch out in different directions and cause each branch’s respective disease. It does seem that the PPARs family is a large branch on this disease tree, and the more we understand what each receptor does, the more we can learn how altered functions create disease. Although the pharmaceuticals are spending lots of money on drugs that try to alter or control PPARs function, remember that nature usually got there first…we just have to find them.

JCEM — Abstracts: Hornung et al. 86 (7): 3108

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Steroid and Cytokine Regulation of MMP Expression in Endometriosis – (10-10-02)

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Steroid and Cytokine Regulation of MMP Expression in Endometriosis

Cutting through the technical jargon, this article brings to light a potentially important factor for treatment of endometriosis. Progesterone is key here. Progesterone inhibits the ability of an enzyme, MMP, to establish endometriosis. This ability of progesterone can itself be inhibited by certain mechanisms. This study finds that the use of retinoic acid (vitamin A related compounds) and transforming growth factor beta (a cytokine controlling cell maturation) can restore progesterone’s protective ability. As added info, many women today, as a result of exposure to way too many exogenous estrogens, go through anovulatory cycles. Without the release of an ovum during a normal menstrual cycle, the body lacks that normal exposure to progesterone that is so needed for normal female reproductive function.

JCEM — Abstracts: Bruner-Tran et al. 87 (10): 4782

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EFFECT OF PLANT LIGNANS ON CVD AND CANCER – (05-29-03)

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Risk of CVD–Related, All-Cause Death & Serum Enterolactone.

There is much evidence suggesting a protective effect of plant lignans (found in whole grains, flaxseed, soy…) on many diseases including CVD and breast and endometrial cancer. However, many of these studies are not raising a fundamental question. Lignans are converted by intestinal bacterial to enterolactone. What impact does the widespread destruction of normal flora with antibiotics have on this conversion rate?

Arch Intern Med — Abstracts: Vanharanta et al. 163 (9): 1099 –

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