Troglitazone Increases VEGF in Diabetic Patients
Remember the new-wonder drug for diabetes? Remember it was pulled off the market because of liver failure. Well, now we also find out that it may increase new blood vessels formation and actually lead to diabetic retinopathy!! It just amazes me how frequently we see drugs on the market that may work in the short term, but actually make the condition worse in the long run. Although this article does not mention it, new blood vessels formation is absolutely required for most tumor growths. Might this drug in the long run lead to increased rates and increased metastasis of certain cancers?
Diabetes — Abstracts: Emoto et al. 50 (5): 1166
(for further reading on conjugated linoleic acid instead of troglitazone… Diabetes — Abstracts: Ryder et al. 50 (5): 1149 http://diabetes.diabetesjournals.org/cgi/content/abstract/50/5/1149